Rabeprazole

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Rabeprazole
Rabeprazole.png
Rabeprazole3d.png
Systematic (IUPAC) name
(RS)-2-([4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole
Clinical data
Trade names Aciphex, Acifix (by Beximco)
AHFS/Drugs.com monograph
MedlinePlus a699060
Licence data US FDA:Finix&SearchType=BasicSearch link
Pregnancy cat.
Legal status
Routes Oral
Pharmacokinetic data
Bioavailability 52%
Metabolism mostly non-enzymatic,
partly hepatic (CYP2C19)
Half-life 1 - 1.5 hours
Excretion 90% renal
Identifiers
CAS number 117976-89-3 YesY
ATC code A02BC04
PubChem CID 5029
DrugBank DB01129
ChemSpider 4853 YesY
UNII 32828355LL YesY
ChEBI CHEBI:8768 YesY
ChEMBL CHEMBL1219 YesY
PDB ligand ID RZX (PDBe, RCSB PDB)
Chemical data
Formula C18H21N3O3S 
Mol. mass 359.444 g/mol
 YesY (what is this?)  (verify)

Rabeprazole /ˌræ.ˈbɛp.ræ.zɔːl/ is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as the sodium salt under the brand names AcipHex (/ˈæsɨfɛks/, referring to pH) in the US, Pariet in Europe, Brazil, Canada, Japan, Russia and Australia. Rabonik in India, and Zechin in Pakistan.In Bangladesh Rabeprazole is sold under the brand name of Acifix by Beximco Pharma

Indications and usage[edit]

Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GORD); maintaining healing and reducing relapse rates of heartburn symptoms in patients with GORD; treatment of daytime and nighttime heartburn and other symptoms associated with GORD; long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.

  • Gastric ulcer (GU)
  • Peptic ulcer disease (PUD)
  • Maintenance of healing of erosive or ulcerative GORD
  • Healing of erosive and ulcerative GORD
  • Healing of duodenal ulcers.
  • Treatment of symptomatic GORD
  • Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
  • Helicobacter pylori eradication to reduce risk of duodenal ulcer recurrence

Contraindications[edit]

  • hypersensitivity to rabeprazole, substituted benzimidazoles or any of components of its pharmaceutical forms.
  • lactation: Thomson Lactation Ratings: Infant risk cannot be ruled out.

Restriction of usage[edit]

Bottle of rabeprazole 20 mg tablets.
  • acute hepatic failure
  • pediatric use in patients under 18 years of age (there are insufficient data about safety and efficiency of rabeprazole in this group of patients)

Side effects[edit]

Rabeprazole adverse reactions/side effects include[citation needed]:

Antacid preparations such as rabeprazole by suppressing acid mediated break down of proteins, leads to an elevated risk of developing food or drug allergies. This happens due to undigested proteins then passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with only long-term use or with short-term use as well.[1]

Drug interactions[edit]

Rabeprazole decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antacids. Rabeprazole is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin).

Overdosage[edit]

Studies in mice and rats indicated the symptoms of acute toxicity due to overdose included: hypoactivity, labored respiration, convulsion, diarrhea, tremor, and coma. A study in dogs indicated that a dose of 2000mg/kg was not lethal.

Formulations and brand names[edit]

Rabeprazole as kepreb 20 ( Kepler Healthcare ), "Elpizole" (Orchid Chemicals & Pharmaceuticals), Elpizole-20 (Orchid Chemicals & Pharmaceuticals), Rablet (Lupin), Acigard (3D), AcipHex, Rabeloc, Pariet, Rabider (Duta Formulations) Rabsiv 20 (Saharsh Biologicals) is supplied in:

References[edit]

  1. ^ Pali-Schöll I, Jensen-Jarolim E (April 2011). "Anti-acid medication as a risk factor for food allergy". Allergy 66 (4): 469–77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928. 
  • Morii M, Takata H, Fujisaki H, Takeguchi N., The potency of substituted benzimidazoles such as E3810, omeprazole, Ro 18-5364 to inhibit gastric H+, K(+)-ATPase is correlatedwith the rate of acid-activation of the inhibitor, Biochem. Pharmacol. 1990 Feb 15;39(4):661-7.
  • Prakash A, Faulds D., Rabeprazole, Drugs. 1998 Feb;55(2):261-7; discussion 268.

External links[edit]