Acrivastine

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Acrivastine
Acrivastine.svg
Systematic (IUPAC) name
(E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridin-2-yl}prop-2-enoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682619
Pregnancy cat.
Legal status
Routes oral
Pharmacokinetic data
Half-life 1.5 hours
Excretion Renal
Identifiers
CAS number 87848-99-5 N
ATC code R06AX18
PubChem CID 5284514
ChemSpider 4447574 YesY
UNII A20F9XAI7W YesY
KEGG D02760 YesY
ChEMBL CHEMBL1224 YesY
Chemical data
Formula C22H24N2O2 
Mol. mass 348.438 g/mol
 N (what is this?)  (verify)

Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking Histamine H1 receptors.

This non-sedating antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories, not to be confused with Benadryl Once a Day, which is cetirizine and is also sold by McNeil in the UK. It is available as an over-the-counter medication in the UK, also offered with pseudoephedrine under the Benadryl brand

In the U.S., acrivastine is the active ingredient in the Semprex brand. Semprex-D is also acrivastine-based, but contains a decongestant, pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals.[1]

Comparisons with other popular antihistamines[edit]

Unlike cetirizine or loratadine, the standard dosage of which is one tablet every day, a single acrivastine tablet may be taken up to three times a day.[2] Not to be taken by over 65's, pregnant women or people with compromised liver or kidney function.

References[edit]

  1. ^ SEMPREX-D - acrivastine and pseudoephedrine hydrochloride capsule U.S. National Library of Medicine, National Institutes of Health, May 2008
  2. ^ "Benadryl Allergy Relief". electronic Medicines Compendium (eMC). 2014. Retrieved 4 July 2014.