Acrospiroma

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Acrospiroma
Classification and external resources
Nodular hidradenoma - intermed mag.jpg
Micrograph showing an acrospiroma. H&E stain.

An acrospiroma (also known as a eccrine hidradenoma, clear-cell hidradenoma, hidroacanthoma simplex, nodulocystic hidradenoma)[1]:665 is a relatively rare type of adnexal tumor originating from the sweat gland.[2] There are several types of sweat gland-derived tumors that characterized by subtle histologic differences and slightly different clinical presentations. Generally, tumors are divided into eccrine vs aprocrine gland types. Acrospiromas were traditionally thought to display purely eccrine differentiation (akral "peripheral" + spiroma "epithelial tumor of sweat gland"), but it is now accepted that these tumors can show both eccrine and ductal apocrine differentiation. Thus, it may be more accurate to classify these tumors as "mixed" eccrine or apocrine tumors, or as hidradenoma of eccrine/apocrine sub-type. This is in contrast to more purely eccrine tumors, e.g. dermal duct tumor, hidroacanthoma simplex, or eccrine poromas.[3][4]

Acrospiromas are by definition benign, with malignant transformation very rare.[5] Surgical excision is usually curative and local recurrences are rare, although malignant tumors may metastasize.[3]

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  1. ^ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  2. ^ Laws RA, English JC 3rd, Elston DM (1996). "Acrospiroma: a case report and review". Cutis 58 (5): 349–51. PMID 8934076. 
  3. ^ a b Griffiths, C; Cox, N; Breathnach, S et al., eds. (2010). "53. Tumours of the Skin Appendages: Eccrine or aprocrine/follicular tumours". Rook's Textbook of Dermatology - 8th Ed. Chichester, West Sussex: John Wiley & Sons Ltd. ISBN 1-4051-6169-8. 
  4. ^ Griffiths, C; Cox, N; Breathnach, S et al., eds. (2010). "53. Tumours of the Skin Appendages: Eccrine gland tumours". Rook's Textbook of Dermatology - 8th Ed. Chichester, West Sussex: John Wiley & Sons Ltd. ISBN 1-4051-6169-8. 
  5. ^ Hernandez, PE; Cestoni, PR (1985). "Nodular hidradenoma and hidradenocarcinoma. J Am Acad Dermatol 1985; 12: 15-20.". J Am Acad Dermatol 12: 15-20.