Actavis

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Actavis plc
Public
Traded as NYSEACT
S&P 500 Component
Industry Brand and generic pharmaceuticals, and pharmaceutical research and development.
Founded Libertyville, Illinois, United States (Spring 1984)
Founder Allen Chao, Ph.D. and David Hsia, Ph.D.
Headquarters Dublin, Ireland and Parsippany-Troy Hills, New Jersey, United States.
Number of locations
36 manufacturing facilities, 17 global R&D centers, distribution centers and marketing/sales facilities worldwide.
Area served
Worldwide
Key people
Paul Bisaro, Executive Chairman, Brenton L. Saunders CEO & President
Products Brand and generic pharmaceuticals
Revenue US$ 13 billion(2014)
Number of employees
25,000 employees worldwide (2014)
Website www.actavis.com
Actavis facility in Iceland

Actavis plc NYSEACT New York Stock Exchange is a pharmaceutical company focused on developing, manufacturing, and commercializing generic, branded pharmaceutical and biosimilar products. The company has global headquarters in Dublin, Ireland and administrative headquarters in Parsippany-Troy Hills, New Jersey, United States.

Actavis is the world's third-largest generics prescription drug manufacturer. The company develops, manufactures and markets generic, branded generic, and Over-the-Counter (OTC) products in more than 60 countries. The company is ranked in the top 3 in 12 global markets, the top 5 in 16 global markets, and in the top 10 in 33 global markets. Actavis also develops and out-licenses generic pharmaceutical products outside the U.S. through its Medis third-party business, the world’s largest generic pharmaceutical out-licensing business. Medis has more than 300 customers globally, and offers a broad portfolio of more than 200 products.

Actavis markets a broad portfolio of branded pharmaceuticals and is developing new medicines for patients suffering from diseases principally in the central nervous system, gastroenterology, women’s health, urology, cardiovascular, respiratory and anti-infective therapeutic categories.

Actavis is also developing and marketing biosimilars products in women’s health, oncology and other therapeutic categories, and currently has a portfolio of five biosimilar products in development.

Actavis has more than 35 manufacturing and distribution facilities around the world, with a capacity of approximately 40 billion units annually. Actavis Global Operations also includes Anda, Inc., the fourth-largest U.S. generic pharmaceutical product distributor in the United States.

On February 18, 2015, Actavis announced its intention to change its name to Allergan, following the contemplated close of the Company's acquisition of Allergan, expected in the second quarter of 2015. The name change is dependent on shareholder approval [1]

History[edit]

The company was founded in the spring of 1983,[2] when, with funding from friends and family, colleagues Allen Chao, Ph.D. and David Hsia, Ph.D., began a small drug development enterprise. Just two months later, the founders established an initial product development and analytical laboratory with six employees (including both founders) in a leased space in Libertyville, Illinois.

By late fall of the same year, the company moved to Southern California into an initial 2,000-square-foot (190 m2) leased facility in Corona, and the development and manufacturing of generic pharmaceuticals began. The Corona site became the corporate headquarters for the rapidly expanding U.S. company.


Company evolution[edit]

The '90s[edit]

Throughout its history, Actavis has expanded both organically and as the result of strategic acquisitions that brought broader product lines, enhanced drug delivery technologies, and ultimately branded pharmaceutical products to the company. In 1993, Actavis, then Watson, announced its initial public offering (IPO) of shares of common stock. The company was initially listed on the NASDAQ under the ticker symbol WATS. The company moved to the New York Stock Exchange (NYSE) in 1997, and began trading under the symbol WPI.

2000 to 2009[edit]

In 2000, the company acquired Schein Pharmaceutical, Inc., an acquisition that more than doubled the company’s size. In that same year, the group reported revenues in excess of $1 billion. In the fall of 2006, it acquired Andrx Corporation, a Fort Lauderdale, FL–based pharmaceutical company, making it the third largest specialty pharmaceutical company based on total prescriptions dispensed. In 2007, Dr. Allen Chao retired as President and Chief Executive Officer (CEO) and was succeeded by Paul M. Bisaro. The company’s international presence began with the acquisition of the Arrow Group in 2009, providing the company with commercial presence in more than 20 international markets. As a result of the Arrow acquisition, the company also acquired the biopharmaceutical development organization Eden Biodesign in Liverpool, UK.

2011 to the present day[edit]

The company further strengthened its presence in Europe with the acquisition of Specifar Pharmaceuticals S.A. in May 2011. Based in Athens, Greece, Specifar is a generic pharmaceutical developer, manufacturer and marketer of products sold under its own and customer labels. In December 2011, a collaboration agreement with Amgen was announced—to develop and commercialize oncology biosimilars.

In January 2012, the company acquired Ascent Pharmahealth Ltd, the Australia and Southeast Asia generic pharmaceutical business of Strides Acrolab Ltd. As a result of the acquisition Watson became the fifth largest generic pharmaceutical company in Australia based on revenue, and the largest generics company in Singapore, with an established commercial base in Malaysia, Hong Kong, Vietnam, and Thailand. In November 2012, Watson acquired the Switzerland based, global generics company Actavis Group for EUR4.25 billion, creating the world’s third largest generics company, with a leading position in key established commercial markets including the U.S., UK, Nordics, Canada, Australia, and emerging markets in Central and Eastern Europe, and Russia. Following the acquisition, Watson adopted Actavis' name for its global operations.

In 2011, the company moved its corporate headquarters from Corona, California to Parsippany, New Jersey. The new LEED-certified corporate headquarters at the Morris Corporate Center in Parsippany was formally dedicated on June 9, 2011.

On October 1, 2013 Actavis acquired Irish pharmaceutical company Warner Chilcott plc in a stock-for-stock transaction valued at approximately $8.5 billion.[3] The combination created a company with approximately $10 billion in anticipated combined annual 2013 revenue, and the third-largest U.S. specialty pharmaceutical company with approximately $3 billion in annual revenue focused on the core therapeutic categories of women’s health, urology, gastroenterology and dermatology. In association with the merger the company relocated its corporate headquarters to Ireland while maintaining its operational headquarters in Parsippany, taking advantage of the lower (17% vs. 35% in the United States) Irish corporate tax rate. This deal inspired a series of similar moves by other drug companies and led to new Treasury Department regulations limiting the ability of companies to perform such inversions, although Actavis was exempt from these regulations as its move abroad had already been completed.[4] CEO Paul Bisaro stated that in making the inversion, they were trying to "level the playing field" given the high corporate tax rate in the United States.[5]

In 2014 Actavis announced its intention to acquire Allergan, the manufacturer of Botox. The acquisition is expected to close in the second quarter of 2015,[6] Completion of the deal would increase its market capitalization to $147 billion.[7][8]

On July 1, 2014. Actavis announced that it had completed its acquisition of Forest Laboratories in a cash and equity transaction valued at approximately $25 billion. Following the acquisition, the company restructured its executive leadership, with Paul Bisaro being named Executive Chairman, and Brent Saunders being appointed CEO and President of the combined organization.[9]

On October 6, 2014 Actavis announced its intention to acquire Durata Therapeutics for more than $675 million, the deal will give the company access to the already-marketed infectious disease drug, dalbavancin.[10] On October 22, 2014 the company announced it had signed a $40+ million option to acquire Rhythm Health including its Phase IIb-ready drug candidate relamorelin (RM-131), a peptide ghrelin agonist, designed to treat diabetic gastroparesis.[11]

In December 2014 the company (along with Adamas Pharmaceuticals) announced that they had received FDA approval for Namzaric (MDX-8704) for the treatment of Alzheimers.[12]

Locations and facilities[edit]

Global headquarters[edit]

The company's global headquarters are located in Dublin, Ireland and administrative headquarters are located in Parsippany, New Jersey, USA.

Sales and marketing offices[edit]

Sales and marketing offices are located in five continents:

  • Americas
    • USA, Canada and Brazil.
  • Europe
    • Austria, the Balkans, the Baltics, Bulgaria, CIS, Czech Republic, Greece, Hungary, Ireland, Nordic region, Malta, Poland, Portugal, Romania, Russia, Serbia, Slovenia, Slovakia, Switzerland, Turkey, Ukraine, and UK.
  • Middle East and Africa
    • United Arab Emirates and South-Africa.
  • Australasia
    • Australia, China, Hong Kong, Indonesia, Japan, New Zealand, Malaysia, Singapore, Thailand and Vietnam.
  • Third-party sales
    • Germany, Greece, Iceland and the United Kingdom.

Manufacturing facilities[edit]

The company has 36 manufacturing facilities in five continents providing the company with a core leadership position in modified release products, solid oral dosages, transdermals, semi-solids, liquids and injectables.

The company’s manufacturing facilities are located in Brazil, Bulgaria, Canada, China, Germany, Greece, France, Iceland, India, Indonesia, Ireland, Italy, Malta, Puerto Rico, Romania, Russia, Singapore, Serbia, Thailand, UK and USA.

Research and development facilities[edit]

Actavis has 17 global R&D facilities focusing on the development of modified release products, solid oral dosages, transdermals, semi-solids, liquids and injectables around the world.

The company’s R&D facilities are located in Belgium, Bulgaria, Iceland, Italy, India, Indonesia, Ireland, Northern Ireland, Romania, UK and USA.

Specialty pharmaceuticals: India, Romania, UK, and USA. Branded pharmaceuticals: Salt Lake City, New Jersey, USA, Liege, Belgium and Liverpool, UK (biologics).

References[edit]

External links[edit]