Activating transcription factor

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In molecular biology, activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors.[1] First, they have been described as members of the CREB/ATF family,[2] whereas it turned out later that some of them might be more similar to AP-1-like factors such as c-Jun or c-Fos.[3]

Genes include ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7.

References[edit]

  1. ^ van Dam H, Castellazzi M (2001). "Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis". Oncogene 20 (19): 2453–64. doi:10.1038/sj.onc.1204239. PMID 11402340. 
  2. ^ Karin M1, Smeal T (1992). "Control of transcription factors by signal transduction pathways: the beginning of the end". Trends Biochem Sci 17 (10): 418–22. PMID 1455510. 
  3. ^ "Classification of Human Transcription Factors (TFClass)". 

External links[edit]