Activation syndrome is a form of sometimes suicidal or homicidal stimulation or agitation that can occur in response to some psychoactive drugs. A study of paroxetine found that 21 out of 93 (23 percent) of youth taking Paxil reported manic-like symptoms which included hostility, emotional lability and nervousness. Pfizer has denied that sertraline can cause such effects. Approximately 25 to 40 percent of patients who take tricyclic antidepressants experience activation syndrome upon initial titration.
- AD Nelson (2007), Adolescents and Antidepressants: Analyzing a Social Scientific Controversy
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