Activin receptor
From Wikipedia, the free encyclopedia
An Activin receptor is a receptor which binds activin.
Types include:
These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain[1][2][3].
[edit] Human proteins containing this domain
ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; BMPR1A; BMPR1B; BMPR2; TGFBR1;
[edit] References
- ^ Wrana JL, Attisano L (1996). "Signal transduction by members of the transforming growth factor-beta superfamily". Cytokine Growth Factor Rev. 7 (4): 327–339. doi:10.1016/S1359-6101(96)00042-1. PMID 9023056.
- ^ Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature 370 (6488): 341–347. doi:10.1038/370341a0. PMID 8047140.
- ^ Massague J, Weis-Garcia F (1996). "Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals". Cancer Surv. 27: 41–64. PMID 8909794.
[edit] External links
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| Type I cytokine receptor |
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| Receptor protein serine/threonine kinase |
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| Receptor tyrosine kinase |
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| Tumor necrosis factor receptor |
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| Ig superfamily |
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| Other/ungrouped |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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| TGF beta superfamily of ligands |
TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other ( Activin and inhibin, Anti-müllerian hormone, Nodal)
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TGF beta receptors
(Activin, BMP) |
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| Transducers/SMAD |
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| Ligand inhibitors |
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| Coreceptors |
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| Other |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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This article incorporates text from the public domain Pfam and InterPro IPR000472
