The town is named for Michael S. Acuff, who arrived in the area in 1891. Acuff's first school was constructed in 1902 and the town had a post office from 1903 to 1912. In 1942, the Acuff school consolidated with, and is currently served by, the Roosevelt Independent School District. During the 1940s Baptists and Methodists shared the same church and the population swelled from (no figures available) to 50 people in the 1950s. The current estimated population is 30.
The main crop in the area is cotton. The early settlers cleared the land from prairie grass and mesquite trees using plows pulled by mules. Most of the current landowners are the children and grandchildren of the original settlers.