Acute chest syndrome

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Acute chest syndrome
Classification and external resources
ICD-9 517.3

The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in patients with sickle cell anemia. This condition commonly manifests with pulmonary infiltrate on a chest x-ray.[1]


Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickeling, and vaso-occlusion.


The crisis is a common complication in sickle-cell patients and can be associated with one or more symptoms including fever, cough,excruciating pain, sputum production, dyspnea, or hypoxia. [2]


Broad spectrum antibiotics to cover common infections like strep pneumoniae and mycoplasma, pain control, and blood transfusion. Acute chest syndrome is an indication for exchange transfusion.


It may result in death,[3] and it is one of the most common causes of death for sickle cell patients.[4]

See also[edit]


  1. ^ Betty Pace (2007). Renaissance of Sickle Cell Disease Research in the Genome Era. Imperial College Press. pp. 81–. ISBN 978-1-86094-645-5. Retrieved 15 June 2010. 
  2. ^ Johnson, CS (1995). "Sickle-Cell Disease: The Acute Chest Syndrome". 
  3. ^ "acute chest syndrome" at Dorland's Medical Dictionary
  4. ^ Kumar, Abbas, Fausto. Robbins and Cotran: The Pathologic Basis of Disease, Page 631