Acute chest syndrome

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Acute chest syndrome
Classification and external resources
ICD-9 517.3

The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in patients with sickle cell anemia. This condition commonly manifests with pulmonary infiltrate on a chest x-ray.[1]

Cause[edit]

Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickeling, and vaso-occlusion.

Symptoms[edit]

The crisis is a common complication in sickle-cell patients and can be associated with one or more symptoms including fever, cough,excruciating pain, sputum production, dyspnea, or hypoxia. [2]

Treatment[edit]

Broad spectrum antibiotics to cover common infections like strep pneumoniae and mycoplasma, pain control, and blood transfusion. Acute chest syndrome is an indication for exchange transfusion.

Prognosis[edit]

It may result in death,[3] and it is one of the most common causes of death for sickle cell patients.[4]

See also[edit]

References[edit]

  1. ^ Betty Pace (2007). Renaissance of Sickle Cell Disease Research in the Genome Era. Imperial College Press. pp. 81–. ISBN 978-1-86094-645-5. Retrieved 15 June 2010. 
  2. ^ Johnson, CS (1995). "Sickle-Cell Disease: The Acute Chest Syndrome". 
  3. ^ "acute chest syndrome" at Dorland's Medical Dictionary
  4. ^ Kumar, Abbas, Fausto. Robbins and Cotran: The Pathologic Basis of Disease, Page 631