Acutissimin A

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Acutissimin A
Chemical structure of acutissimin A
CAS number 108906-66-7 N
PubChem 44559699
ChemSpider 10258694 YesY
Jmol-3D images Image 1
Molecular formula C56H38O31
Molar mass 1206.88 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Acutissimin A is a flavono-ellagitannin, a type of tannin formed from the linking of a flavonoid with an ellagitannin.

In 2003, scientists at Institut Européen de Chimie et Biologie in Pessac, France found that when the oak tannin vescalagin interacts with a flavanoid in wine acutissimin A is created. In separate studies this phenolic compound has been shown to be 250 times more effective than the pharmaceutical drug Etoposide in stopping the growth of cancerous tumors.[1][2][3]

See also[edit]


  1. ^ Quideau S, Jourdes M, Saucier C, Glories Y, Pardon P, Baudry C (December 2003). "DNA topoisomerase inhibitor acutissimin a and other flavano-ellagitannins in red wine". Angewandte Chemie 42 (48): 6012–4. doi:10.1002/anie.200352089. PMID 14679557. 
  2. ^ Kashiwada Y, Nonaka G, Nishioka I, Chang JJ, Lee KH (August 1992). "Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents". Journal of Natural Products 55 (8): 1033–43. doi:10.1021/np50086a002. PMID 1431932. 
  3. ^ Quideau, StéPhane; Jourdes, Michael; Saucier, Cédric; Glories, Yves; Pardon, Patrick; Baudry, Christian (2003). "DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano-Ellagitannins in Red Wine". Angewandte Chemie 115 (48): 6194–6. doi:10.1002/ange.200352089. "While it would be quite inappropriate to infer from the presence of acutissimin A in red wine that this beverage possesses antitumor properties, our work shows for the first time that wine contains polyphenolic molecules displaying both ellagitannin and flavanoid structural features."