Adaptins are proteins that mediate the formation of vesicles by clathrin-coated pits, through interaction with membrane-bound receptors. There are several types of adaptin, each related to a different group of such receptors.
Adaptins cluster to form the AP2 complex.
The Adaptin complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma):
- complex 1
- complex 2
- complex 3
- complex 4
- complex 5
- complex 5 has been discovered at the university of Alberta, Canada, little is yet known of the internal constructs that make up the complex.
- Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
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