Adaptor-related protein complex 2, alpha 1

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Adaptor-related protein complex 2, alpha 1 subunit
Protein AP2A1 PDB 1gw5.png
PDB rendering based on 1gw5.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM601026 MGI101921 HomoloGene68997 GeneCards: AP2A1 Gene
Species Human Mouse
Entrez 160 11771
Ensembl ENSG00000196961 ENSMUSG00000060279
UniProt O95782 P17426
RefSeq (mRNA) NM_014203 NM_001077264
RefSeq (protein) NP_055018 NP_001070732
Location (UCSC) Chr 19:
50.27 – 50.31 Mb
Chr 7:
44.9 – 44.93 Mb
PubMed search [1] [2]

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.[1]

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.[2]


Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2[3] and NUMB.[3]


  1. ^ Robinson MS (April 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". J Cell Biol 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002. 
  2. ^ "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". 
  3. ^ a b Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (September 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. (England) 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. 

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