Addressin

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Mucosal vascular addressin cell adhesion molecule 1
1BQS.pdb.png
Crystallographic structure of human mucosal addressin cell adhesion molecule 1.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MADCAM1 ; MACAM1
External IDs OMIM102670 MGI103579 HomoloGene8413 ChEMBL: 4467 GeneCards: MADCAM1 Gene
Orthologs
Species Human Mouse
Entrez 8174 17123
Ensembl ENSG00000099866 ENSMUSG00000020310
UniProt Q13477 Q61826
RefSeq (mRNA) NM_130760 NM_013591
RefSeq (protein) NP_570116 NP_038619
Location (UCSC) Chr 19:
0.49 – 0.51 Mb
Chr 10:
79.66 – 79.67 Mb
PubMed search [1] [2]

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.[2][3][4]

Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.[5] The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function[edit]

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.[2]

See also[edit]

References[edit]

  1. ^ PDB 1BQS; Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (June 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832. 
  2. ^ a b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1". 
  3. ^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404. 
  4. ^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. 
  5. ^ Addressin at eMedicine Dictionary


Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.