Youth and early years
She was born in Los Lunas, New Mexico in 1881 to conservative parents who traced their heritage to eleventh-century Spain. Otero-Warren attended Maryville University in Saint Louis, Missouri from 1892 to 1894. In 1894, she moved to Santa Fe, New Mexico when her uncle, Miguel Otero, was appointed territorial governor of New Mexico in 1894.
In 1914, Otero-Warren worked with the woman's suffrage campaign in New Mexico with Alice Paul's Congressional Union (forerunner of the Woman's Party). She soon rose to leadership ranks in the state Congressional Union, rallying support among both Spanish and English-speaking communities. Otero-Warren lobbied New Mexico congressmen to vote in favor of the 19th Amendment. From 1917 to 1929, she served as one of New Mexico's first female government officials: Santa Fe Superintendent of Instruction, and chair of the State Board of Health. She was named Inspector of Indian Schools in Santa Fe County in 1923 and was appointed as state director of the federal Civilian Conservation Corps (CCC) by President Franklin D. Roosevelt. Otero-Warren won the Republican Party nomination to run for the U.S. House of Representatives in 1922. However, she was defeated by Democrat John Morrow, receiving 45.6% of the vote.
- "National Women's History Project". National Women's History Project. Archived from the original on 2009-03-07. Retrieved 2009-03-07.
- "WOW Museum: Western Women's Suffrage - New Mexico". Women of the West. Archived from the original on 2009-03-07. Retrieved 2009-03-07.