Adipose differentiation-related protein

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Perilipin 2
Symbols PLIN2 ; ADFP; ADRP
External IDs OMIM103195 MGI87920 HomoloGene872 GeneCards: PLIN2 Gene
RNA expression pattern
PBB GE ADFP 209122 at tn.png
More reference expression data
Species Human Mouse
Entrez 123 11520
Ensembl ENSG00000147872 ENSMUSG00000028494
UniProt Q99541 P43883
RefSeq (mRNA) NM_001122 NM_007408
RefSeq (protein) NP_001113 NP_031434
Location (UCSC) Chr 9:
19.11 – 19.15 Mb
Chr 4:
86.65 – 86.67 Mb
PubMed search [1] [2]

Adipose differentiation-related protein, also known as perilipin 2 (PLIN2), ADRP or adipophilin, is a protein which in humans is encoded by the ADFP gene.[1]


Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation.[1]

Pre-adipocytes are undifferentiated fibroblasts that can be stimulated to form adipocytes. Recent studies shed light into potential molecular mechanisms in the fate determination of pre-asipocytes although the exact lineage of adipocyte is still unclear.[2][3]


  1. ^ a b "Entrez Gene: ADFP adipose differentiation-related protein". 
  2. ^ "Scientists closer to finding what causes the birth of a fat cell". ScienceDaily. 
  3. ^ Coskun, Huseyin; Summerfield, Taryn LS; Kniss, Douglas A; Friedman, Avner (2010). "Mathematical modeling of preadipocyte fate determination". Journal of Theoretical Biology 265 (1): 87–94. doi:10.1016/j.jtbi.2010.03.047. .

Further reading[edit]