Admixture mapping
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It has been suggested that this article or section be merged with Genetic admixture. (Discuss) Proposed since March 2010. |
Admixture mapping is a method of gene mapping that makes use of a population of mixed ancestry (an admixed population) to find the genetic loci that contribute to differences in diseases or other phenotypes found between the different ancestral populations. The method is best applied to populations with recent admixture from two populations that were previously genetically isolated for tens of thousands of years, such as African Americans (admixture of African and European populations). The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest. Genetic markers which differ in frequency between the ancestral populations are needed across the genome.[1]
Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease-causing or phenotype-causing genetic variants between populations. In an admixed population, these causal variants will occur more frequently on chromosomal segments inherited from one or another ancestral population. The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped.[2] These include hypertension, multiple sclerosis, BMI, and prostate cancer in African Americans. By 2010, high-density mapping panels had been constructed for African Americans, Latino/Hispanics, and Uyghurs.
[edit] See also
[edit] References
- ^ Shriver MD, Mark D, et al. 2003. Skin Pigmentation, biogeographical ancestry and admixture mapping. Hum. Genet. 112, 387-399 (2003)
- ^ Winkler, C. A.; Nelson, G. W.; Smith, M. W. (2010). "Admixture mapping comes of age". Annu Rev Genomics Hum Genet. 11: 65–89. doi:10.1146/annurev-genom-082509-141523. PMID 20594047.
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