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September 27, 1818|
Elliehausen, near Göttingen, Kingdom of Hanover
|Died||November 25, 1884
Leipzig, German Empire
|Institutions||University of Marburg
University of Leipzig
|Alma mater||University of Marburg|
|Doctoral advisor||Robert Bunsen
|Doctoral students||Peter Griess
Aleksandr Mikhailovich Zaitsev
Ernst Otto Beckmann
Alexander Crum Brown
Frederick Guthrie [Note, not primary advisor for all in this list]
|Known for||Kolbe electrolysis,
Kolbe nitrile synthesis
|Notable awards||Davy Medal (1884)|
Hermann Kolbe (Adolph Wilhelm Hermann Kolbe, 27 Sept. 1818–25 Nov. 1884), was a seminal contributor in the birth of modern organic chemistry as Professor at Marburg and Leipzig. Kolbe coined the term synthesis, and contributed to the philosophical demise of vitalism through synthesis of the biologic natural product acetic acid from carbon disulfide, to structural theory via modifications to the idea of "radicals" and accurate prediction of the existence of secondary and tertiary alcohols, and to the emerging array of organic reactions through his Kolbe electrolysis of carboxylate salts, the Kolbe-Schmitt reaction in the preparation of aspirin, and the Kolbe nitrile synthesis. After studies with Wöhler and Bunsen, Kolbe was involved with the early internationalization of chemistry through overseas work in London (with Frankland), and rose through the ranks of his field to edit the Journal für Praktische Chemie, to be elected to the Royal Swedish Academy of Sciences, and to win the Royal Society of London's Davy Medal in the year of his death. Despite these accomplishments and his training a storied next generation of chemists (including Zaitsev, Curtius, Beckmann, Graebe, Markovnikov, etc.), Kolbe is remembered for editing the Journal for more than a decade, where his rejection of Kekulé's structure of benzene, van't Hoff's theory on the origin of chirality, and von Baeyer's reforms of nomenclature were personally critical and linguistically violent. Kolbe died of a heart attack in Leipzig at age 68, six years after the death of his wife, Charlotte. He was survived by four children.
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Kolbe was born in Elliehausen, near Göttingen, Kingdom of Hanover (Germany) as the eldest son of a Protestant pastor. At the age of 13 he entered the Göttingen Gymnasium, residing at the home of one of the professors. He obtained the leaving certificate (the Abitur) six years later. He had become passionate about the study of chemistry, matriculating at the University of Göttingen in the spring of 1838 in order to study with the famous chemist Friedrich Wöhler.
In 1842 he became an assistant to Robert Bunsen at the Philipps-Universität Marburg; he took his doctoral degree there in 1843. A new opportunity arose in 1845, when he became assistant to Lyon Playfair at the new Museum of Economic Geology in London, where he became a close friend of Edward Frankland. From 1847 he was engaged in editing the Handwörterbuch der reinen und angewandten Chemie (Dictionary of Pure and Applied Chemistry) edited by Justus von Liebig, Wöhler, and Johann Christian Poggendorff, and he also wrote an important textbook. In 1851 Kolbe succeeded Bunsen as professor of chemistry at Marburg, and in 1865 he was called to the Universität Leipzig. In 1864, he was elected a foreign member of the Royal Swedish Academy of Sciences.
In 1853 he married Charlotte, the daughter of General-Major Wilhelm von Bardeleben. His wife died in 1876 after 23 years of happy marriage. They had four children.
Work in chemical research
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As late as the 1840s, and despite Friedrich Wöhler's synthesis of urea in 1828, some chemists still believed in the doctrine of vitalism, according to which a special life-force was necessary to create "organic" (i.e., in its original meaning, biologically derived) compounds. Kolbe promoted the idea that organic compounds could be derived from substances clearly sourced from outside this "organic" context, directly or indirectly, by substitution processes. (Hence, while by modern definitions, he was converting one organic molecule to another, by the parlance of his era, he was converting "inorganic"—anorganisch—substances into "organic" ones only thought accessible through vital processes.) He validated his theory by converting carbon disulfide to acetic acid in several steps (1843–45). Kolbe also introduced a modified idea of structural radicals, so contributing to the development of structural theory. A dramatic success came when his theoretical prediction of the existence of secondary and tertiary alcohols was confirmed by the synthesis of the first of these classes of organic molecules. Kolbe was the first person to use the word synthesis in its present day meaning, and contributed a number of new chemical reactions.
In particular, Kolbe developed procedures for the electrolysis of the salts of fatty and other carboxylic acids (Kolbe electrolysis)[non-primary source needed] and prepared salicylic acid, a building block of aspirin in a process called Kolbe synthesis or Kolbe-Schmitt reaction.[non-primary source needed] His method for the synthesis of nitriles is called the Kolbe nitrile synthesis, and with Edward Frankland he found that nitriles can be hydrolyzed to the corresponding acids.
In addition to his own bench research and scholarly and editorial work, Kolbe oversaw student research at Leipzig and especially at Marburg; students spending time under his tutelage included Peter Griess, Aleksandr Mikhailovich Zaitsev (known for Zaitsev's rule predicting the product composition of elimination reactions), Theodor Curtius (discoverer of diazo compounds, hydrazines, and the Curtius rearrangement), Ernst Otto Beckmann (discoverer of the Beckmann rearrangement), Carl Graebe (discoverer of alizarin), Oscar Loew, Constantin Fahlberg, Nikolai Menshutkin, Vladimir Markovnikov (first to describe carbocycles smaller and larger than cyclohexane, and known for Markovnikov's rule describing addition reactions to alkenes), Jacob Volhard, Ludwig Mond, Alexander Crum Brown (first to describe the double bond of ethylene), Maxwell Simpson, and Frederick Guthrie.
Work as journal editor
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Kolbe served for more than a decade as what, in modern terms, would be understood the senior editor of the Journal für Praktische Chemie (Journal of practical chemistry, from 1870 to 1884), Kolbe was sometimes so severely critical of the work of others, especially after about 1874, that some wondered whether he might have been suffering a mental illness. He was intolerant of what he regarded as loose speculation parading as theory, and sought through his writings to save his beloved science of chemistry from what he regarded as the scourge of modern structural theory.
His rejection of structural chemistry, especially the theories of the structure of benzene by August Kekulé, the theory of the asymmetric carbon atom by J.H. van't Hoff, and the reform of chemical nomenclature by Adolf von Baeyer, resulted in vituperative articles in the Journal für Praktische Chemie. Some translated quotes illustrate his manner of articulating the deep conflict between his interpretation of chemistry and that of the structural chemists: "...Baeyer is an excellent experimentor, but he is only an empiricist, lacking sense and capability, and his interpretations of his experiments show particular deficiency in his familiarity with the principles of true science..."[non-primary source needed]
- Rocke, Alan J. (1993). The Quiet Revolution: Hermann Kolbe and the Science of Organic Chemistry. University of California Press. ISBN 0-520-08110-2.
- von Meyer, E. (1884). "Zur Erinnerung an Hermann Kolbe". Journal für Praktische Chemie 30 (1): 417–467. doi:10.1002/prac.18850300143.
Notes and References
- Hermann Kolbe (1849). "Untersuchungen über die Elektrolyse organischer Verbindungen". Annalen der Chemie und Pharmacie 69 (3): 257–372. doi:10.1002/jlac.18490690302.[non-primary source needed]
- Hermann Kolbe (1860). "Ueber Synthese der Salicylsäure". Annalen der Chemie und Pharmacie 113 (1): 125–127. doi:10.1002/jlac.18601130120.[non-primary source needed]
- Hermann Kolbe (1882). "Begründung meiner Urtheile über Ad. Baeyer's wissenschaftliche Qualification". Journal für Praktische Chemie 26 (1): 308–323. doi:10.1002/prac.18820260121.[non-primary source needed]
- Kurzes Lehrbuch der Chemie . 1.Anorganische Chemie . Vieweg, Braunschweig 2. verb. Aufl. 1884 Digital edition by the University and State Library Düsseldorf
- Wiley online library: Advanced Synthesis & Catalysis, ultimate descendent of the Journal für Praktische Chemie, accessed 2 July 2014.
- Journal für Praktische Chemie, the article on the original German journal and its descendents, at the German Wikipedia, accessed 2 July 2014.