Flunisolide

Flunisolide

Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
Trade names	Aerobid
AHFS/Drugs.com	monograph
MedlinePlus	a681048
Pregnancy cat.	?
Legal status	?
Routes	Inhaled
Pharmacokinetic data
Protein binding	40% after oral inhalation
Half-life	1.8 hours
Identifiers
CAS number	3385-03-3 Y
ATC code	R01AD04 R03BA03
PubChem	CID 82153
DrugBank	APRD00976
ChemSpider	74144 Y
UNII	78M02AA8KF Y
KEGG	D00324 N
ChEBI	CHEBI:5106 Y
ChEMBL	CHEMBL1512 Y
Synonyms	6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal
Chemical data
Formula	C24H31FO6
Mol. mass	434.498 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 Y Key:XSFJVAJPIHIPKU-XWCQMRHXSA-N Y
N (what is this?)  (verify)

Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid often prescribed as treatment for allergic rhinitis.

The principal mechanism of action of flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.