Aerotoxic syndrome

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Aerotoxic syndrome is a phrase coined by Harry Hoffman and Chris Winder in 2000, to describe their claims of short-and long-term ill-health effects caused by breathing airliner cabin air which was alleged to have been contaminated to toxic levels (exceeding known, parts per million, safe levels) with atomized engine oils or other chemicals.[1] Repeated investigations of those claims have failed to document that cabin air has ever contained contaminents that exceeded known safe levels. An assessment by the UK's House of Lords Science and Technology Committee found that the claims of health effects were unsubstantiated.[2] An update in 2008 found no significant new evidence.[3] As of 2009 this syndrome is not recognized in medicine.[4][5]

Potential sources of contamination[edit]

Cabin Pressure and Bleed Air Control Panels on a Boeing 737-800

Modern jetliners have an Environmental Control System (ECS) that manages cabin air. Air is drawn from the outside, typically via compressed engine bleed air, while some of the air is recirculated.[6] Airborne contaminants can enter the cabin through the air-supply system. Substances used in the maintenance and treatment of aircraft, including aviation engine oil, hydraulic fluids, cleaning compounds and de-icing fluids, can contaminate the ECS. While ground and flight crews, as well as passengers themselves can be sources of contaminants such as pesticides, "...bioeffluents, viruses, bacteria, allergens, and fungal spores."[6] they have not been implicated as sources of the aerotoxic syndrome.[6][2]

According to an information leaflet from the UK-based Committee on Toxicology (COT) possible sources of poor-quality cabin air include:[7]

  • Engine or APU oil leaks
  • Engine or APU bay leaks
  • Underfloor hydraulic leaks.
  • Ingestion of deicing fluid into APU inlet.
  • Periodic maintenance task that is required to clean the forward galley oven.
  • Inappropriate or excessive use of dry ice by caterers.
  • Toilet fluid spillage, leakage and also unapproved mixing of differenoxic syndromet disinfectant fluids within the toilet.
  • Leakage of the rain repellent system, or rain repellent contamination within the cabin or flightdeck.
  • Spillage within baggage bays.
  • Items stowed in overhead baggage bins.
An Airbus A-320 being de-iced before take-off

Jet engines require synthetic oils for lubrication. These oils contain ingredients such as tricresyl phosphate (TCP), an organophosphate, which can be toxic to humans in quantities much larger than are found in aviation engine oil.[2] Engine bearing seals are installed to ensure that critical engine bearings are continuously lubricated, and to prevent engine oil from leaking into the compressed air stream. If a bearing seal fails and begins to leak, depending on the location of the seal, some amount of engine oil may be released into the compressed air stream. Oil leaks may be detected by an odour akin to hot frying-pan fume, or, in more serious cases, by smoke in the cabin.[2] This is known in the industry as a fume event.[8]


A yearlong Australian Senate Investigation in 2000 received evidence of some "successful applications for workers’ compensation" for illness which the applicants attributed to fumes on the BAe 146. Approximately 20 crew members describe oil fumes leaking into the aircraft cabin. That investigative committee concluded "the issue of fume contaminants should also be considered a safety issue with regard to the ability of cabin crew to properly supervise the evacuation of an aircraft and the ability of passengers to take part in an evacuation".[9]>

On 5 November 2000, both the captain and first officer of a Jersey European Airways BAe 146 became unwell while landing at Birmingham International Airport. [10]:1 Both became nauseous, and the pilot experienced double vision and had difficulty judging height, but managed to land the aircraft safely.[10]:3-4 Both pilots were taken to hospital but no cause for their illness was found.[10]:1 The incident investigation report concluded that "There is circumstantial evidence to suggest that the flight crew on G–JEAK were affected by contamination of the air supply, as a result of oil leakage from the auxiliary power unit (APU) cooling fan seal into the APU air stream, and into the ECS system ducting. This contamination allowed fumes to develop, a proportion of which entered the cabin and cockpit air supply."[10]:56

The report noted that both captain and first officer had visited the forward toilet before the onset of their symptoms. About the same time of the G-JEAK incident, another operator reported overuse of a disinfectant (formaldehyde) for the toilets and to clean the galley floor and then inhalation of the fumes from that chemical, would produce the identical symptoms reported by both the captain and first officer of G-JEAK. "The CAA notified UK Operators at that time (CAA ref. 10A/380/15, dated 2 August 1996) of this potential hazard, as the misuse of this agent was apparently widespread."[10]:31


In 1986, the United States Congress commissioned a report by the National Research Council (NRC) into cabin air quality.[6] The report recommended a ban on smoking on aircraft in order to improve air quality, which was brought into effect by the FAA soon after.[11]

Research commissioned by the UK government's Department for Transport (DfT) and published in 2000 found no link to long term health. The UK Parliament's Select Committee on Science and Technology concluded in its response to the many complaints received "from a number of witnesses, particularly the Organophosphate Information Network, BALPA, and the International Association of Flight Attendants, expressing concerns about the risk of TOCP poisoning for cabin occupants, particularly for crew who might be subjected to repeated exposure in some aircraft types, as a result of oil leaking into the cabin air supply,":[2]

"This question - including the potential effects on aircrew from any long-term exposure - has been looked at in much greater detail by a Committee of the Australian Senate inquiring into particular allegations of such contamination in the BAe 146. Although its Report[58] referred extensively to cabin air quality and chemical contamination in the aircraft, and recommended that the engine lubricating oil used (a Mobil product) be subjected to a further hazardous chemical review, it made no specific points about TCP or TOCP that have given us additional concerns[59]. The absence of confirmed cases of TOCP poisoning from cabin air and the very low levels of TOCP that would be found in even the highly unlikely worst case of contamination from oil leaking into the air supply lead us to conclude that the concerns about significant risk to the health of airline passengers and crew are not substantiated."[2]

In 2009 the UK House of Commons Library service to Members of Parliament summarized the research into a "relationship between the [engine oil chemical] leaks and these health symptoms" as inconclusive, citing "problems with identifying the exact chemical that might be entering the air supply and therefore identifying what impact it may have on health" and "reports of problems with fumes and/or health symptoms not being reported correctly".[12]

In 2011, mass spectrometric protocols were described which allow documenting exposures of individuals. [13] A 2011 Aircraft Cabin Air Sampling Study was published in 2 parts:[14]

According to a 2008 report by Michael Bagshaw, Aviation Medicine Director at King's College London, there have been no peer-reviewed recorded cases of neurological harm in humans following TCP exposure.[15] He pointed to an unpublished report from the Medical Toxicology Unit at Guy's Hospital in 2001 which looked at all exposures dating back to 1943 that showed that all documented exposures were to high concentrations greatly in excess of the amount present in jet oil.

In his 2013 paper, "Cabin Air Quality: A review of current aviation medical understanding," Bagshaw noted further:

"A German study in 2013 of 332 crew members who had reported fume/odour during their last flight, failed to detect metabolites of TCP in urine samples. The authors concluded that health complaints could not be linked to TCP exposure in cabin air."

"A syndrome is a symptom complex, consistent and common to a given condition. Sufferers of the ‘aerotoxic syndrome’ describe a wide range of inconsistent symptoms and signs with much individual variability. The evidence was independently reviewed by the Aerospace Medical Association, the US National Academy of Sciences and the Australian CASA Expert Panel. All concluded there is insufficient consistency to establish a medical syndrome, and the ‘aerotoxic syndrome’ is not recognised in aviation medicine."[16]

Sensational media coverage[edit]

In a 2006 article in Aviation Today, Simon Bennett[Notes 1] found that media coverage of contaminated cabin air has been sensationalized, with distortions of facts. He cited headlines such as "You are being gassed when you travel by air," and "Death in the Air" and a sub-title of "Every day, planes flying in and out of London City Airport are slowly killing us." Bennett noted that the article with the latter subtitle stated in its body that the Department of the Environment, Transport and the Regions (DETR) found that oil seal failures occur only once in every 22,000 flights.[17]

The Sunday Sun in an article entitled "Flight Fumes Warning", cited the industry pressure group AOPIS in saying that passengers jetting off to their holidays were unknowingly exposed to deadly chemicals, and that brain damage could result if they breathed the toxic fumes.[17] The Sun also cited the UK Civil Aviation Authority finding that leakage into aircraft cabins is a very rare event occuring only if there is a fault with an aircraft.[17]

When the results of a clinical audit of the "cognitive functioning of aircrew exposed to contaminated air" were submitted by Sarah Mackenzie Ross to the UK government's Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT),[18] some media used it to write articles that were sensational and misleading.[17], wrote that the Ross report "... adds weight to the hypothesis that compounds resembling nerve gas in cabin and flight deck air have caused irreparable neurological damage to aircrew,",[17] though the report itself stated that "[T]he evidence available to us in this audit does not enable us to draw firm conclusions regarding a causal link with exposure to contaminated air."[17]

See also[edit]


  1. ^ Bennett is director of the Scarman Centre's distance-learning MSc in Risk, Crisis and Disaster Management, with a PhD in sociology from Brunel University, London.


  1. ^ 2000_paper5-1 
  2. ^ a b c d e f Select Committee on Science and Technology (15 November 2000). "Chapter 4: Elements Of Healthy Cabin Air". Science and Technology - Fifth Report (Report). House of Lords. Retrieved 5 July 2010.
  3. ^ Lord Alec Broers Broers, Air Travel and Health: An Update, Report with Evidence, 1st Report of Session 2007-08, The Stationery Office, Great Britain: Parliament: House of Lords: Science and Technology Committee, ISBN 0-10-401178-5 
  4. ^ Hale MA, Al-Seffar JA (September 2009). "Preliminary report on aerotoxic syndrome (AS) and the need for diagnostic neurophysiological tests". Am J Electroneurodiagnostic Technol 49 (3): 260–79. PMID 19891417. 
  5. ^ Bagshaw, Michael (July 2013). "Cabin Air Quality: A review of current aviation medical understanding". Aerospace Medical Association. Retrieved 2014-09-28. 
  6. ^ a b c d National Research Council (U.S.), Committee on Air Quality in Passenger Cabins of Commercial Aircraft (6 December 2001). The Airliner Cabin Environment and the Health of Passengers and Crew. National Academies Press. p. 5. ISBN 0-309-08289-7. 
  7. ^
  8. ^ Helen Muir (2007-11-21). "Cabin Air Sampling Study Functionality Test". Cranfield University via Department for Transport. Retrieved 2010-05-13. 
  9. ^ Parliament of the Commonwealth of Australia (2000), Air Safety and Cabin Air Quality in the BAe 146 Aircraft: Report by the Senate Rural and Regional Affairs and Transport References Committee, Commonwealth of Australia, ISBN 0-642-71093-7, retrieved 2012-05-09 
  10. ^ a b c d e "Air Accidents Investigation Branch Report on the incident to BAe 146, G-JEAK during the descent into Birmingham Airport on 5 November 2000". 
  11. ^ United States National Research Council (1986). The Airliner Cabin Environment: Air Quality and safety. National Academic Press. ISBN 0-309-03690-9. 
  12. ^ Louise Smith (25 June 2009). "Cabin Air Quality". Information to Members of Parliament. House of Commons Library. p. 1-14. 
  13. ^ Clement E. Furlong (2011). "Exposure to triaryl phosphates: metabolism and biomarkers of exposure". J Biol Phys Chem. 11: 1–11. doi:10.4024/28FU11A.jbpc.11.04. Retrieved 24 October 2014. 
  14. ^ "Aircraft Cabin Air Sampling Study; Part 1 of the Final Report". Institute of Environment and Health. March 2011. Retrieved 24 October 2014. 
  15. ^ Michael Bagshaw (2008-11-29). "The "Aerotoxic Syndrome"". European Society of Aerospace Medicine. 
  16. ^ Bagshaw, Michael (July 2013). "Cabin Air Quality: A review of current aviation medical understanding". Aerospace Medical Association. Retrieved 2014-09-28. 
  17. ^ a b c d e f Simon A. Bennett (2006-08-26). "Through a Glass Darkly". Aviation Today. Retrieved 2010-04-30. 
  18. ^ Victoria Gill (2006-09-27). "Defra Leaves Organophosphate Study Hanging in the Balance". Royal Society of Chemistry. 

Further reading[edit]

External links[edit]