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Affliction may refer to:
- Affliction Clothing, an American clothing manufacturer and retailer
- Affliction Entertainment, a defunct mixed martial arts promotion company created by Affliction Clothing
- Affliction (album), a 1996 album by Econoline Crush
- Affliction (film), a 1998 American drama by Paul Schrader
- "Affliction" (Star Trek: Enterprise), an episode of Star Trek: Enterprise
- Affliction, a 2013 novel in the Anita Blake: Vampire Hunter series by Laurell K. Hamilton
- Afflictions: Culture & Mental Illness in Indonesia, a 2010-2011 ethnographic documentary film series
- Affliction (novel), a 2013 novel by Laurell K. Hamilton
- Afflicted (film), a 2013 Canadian horror film by Derek Lee and Clif Prowse
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