Afloqualone

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Afloqualone
Afloqualone.svg
Systematic (IUPAC) name
6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 56287-74-2 N
ATC code None
PubChem CID 2040
ChemSpider 1960 YesY
UNII CO4U2C8ORZ YesY
KEGG D01638 YesY
ChEMBL CHEMBL2105918 N
Chemical data
Formula C16H14FN3O 
Mol. mass 283.3
 N (what is this?)  (verify)

Afloqualone (Arofuto) is a quinazolinone-class GABAergicdrug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.[1] It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor ,[2] and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.[3]

See also[edit]

References[edit]

  1. ^ US Patent 3966731 - 2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone
  2. ^ Ochiai T, Ishida R. Pharmacological studies on 6-amino- 2-fluoromethyl- 3-(O-tolyl)- 4(3H)- quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. 1982 Jun;32(3):427-38.
  3. ^ Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. Journal of Dermatology. 1994 Jun;21(6):430-3.