As part of Emperor Haile Selassie's education program, Agegnehu was granted a government scholarship to study at the École nationale supérieure des Beaux-Arts in Paris, France from 1926 to 1933. After his return from Europe, Agegnehu held many art exhibitions. He also worked on commissions for military uniforms, birr currency designs, church murals and portraits.
In 1941, Agegnehu became the assistant director of Ethiopia's new Department of Fine Arts in the Ministry of Education and Fine Arts.
He died of unknown causes in 1950, shortly after finishing the painting Twelve Donkeys.
- "ORTMAA". Retrieved 2008-05-28.
- "Continuity and change: three generations of Ethiopian artists". Retrieved 2008-05-28.
- "Zerihun Yetmgeta: An Ethiopian Modernist". Retrieved 2008-05-28.