Established on 1 April 1941, Aguadulce Airfield's mission was to defend the Panama Canal. Most of its operational history was that of an auxiliary airfield, hosting fighter squadrons. Training of South American air force personnel was also conducted at the field.
With the end of World War II Aguadulce was reduced in scope, with only a skeleton staff. It was closed on 1 March 1948 due to budget reductions. For several years, it was used as a civil airport, but was later closed; today the airfield is abandoned, with the runway still visible but in poor condition.