Ajmaline

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ajmaline
Ajmaline.svg
Systematic (IUPAC) name
(17R,21β)-ajmalan- 17,21-diol
OR
(1R,9R,10S,13R,14R,16S,18S)- 13-ethyl- 8-methyl- 8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17] nonadeca- 2(7),3,5-triene- 14,18-diol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 4360-12-7 YesY
ATC code C01BA05
PubChem CID 20367
DrugBank DB01426
ChemSpider 10469368 YesY
UNII 1PON08459R YesY
KEGG D00199 N
ChEMBL CHEMBL1230919 N
Chemical data
Formula C20H26N2O2 
Molecular mass 326.433 g/mol
 N (what is this?)  (verify)

Ajmaline is an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome.

The compound was first isolated by Salimuzzaman Siddiqui in 1931 [1] from the roots of Rauwolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.[2]

See also[edit]

References[edit]

  1. ^ Siddiqui, S.; Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.
  2. ^ Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.