Economic activities in Akatsi are mainly Subsistence agriculture coupled with vibrant buying and selling. Smuggling of clothing from Lomé in Togo through Aflao (the south-eastern border town of Ghana) to Accra. The trans-West Africa highway linking Lomé to Accra through Akatsi also aids an active male dominated transportation business in Akatsi.
The inhabitants of Akatsi are Ewe's and the main language of any social and economic interaction is Ewe. The inhabitants of Akatsi are primarily Ghanaian nationals who settled down after the exodus of Ewe tribe from Nortsie in Togo to Ghana, making the most spoken language in the town the Ewe language.