|Sir Alan Fersht|
|Born||Alan Roy Fersht
21 April 1943
|Fields||Protein folding, p53 and cancer|
|Alma mater||Gonville and Caius College, Cambridge|
|Thesis||Intramolecular catalysis of ester hydrolysis (1968)|
|Notable students||Greg Winter|
|Known for||Protein folding|
Sir Alan Roy Fersht, FRS, FMedSci (born 21 April 1943) is a British chemist at the Laboratory of Molecular Biology in Cambridge. He is distinguished for his pioneering work on protein folding. Since October 2012, he has been Master of Gonville and Caius College, Cambridge.
Fersht was born on 21 April 1943. He was educated at Sir George Monoux Grammar School, an all-boys grammar school in Walthamstow, London. He went on to study at the Gonville and Caius College, Cambridge, where he was awarded his PhD degree in 1968.
Career and Research
He was Wolfson Research Professor of the Royal Society and Professor of Biological Chemistry at Imperial College London from 1978 to 1988 and was Herchel Smith Professor of Organic Chemistry at Cambridge from 1988 to 2010. He was the Director of the Cambridge Centre for Protein Engineering from 1990 to 2010. He is a Fellow of both Gonville and Caius College and Imperial College.
Alan Fersht is widely regarded as one of the main pioneers of protein engineering, which he developed as a primary method for analysis of the structure, activity and folding of proteins. He has developed methods for the high resolution of protein folding in the sub-millisecond time-scale and has pioneered the method of phi value analysis for studying the folding transition states of proteins. His interests also include protein misfolding, disease and cancer.
Awards and honours
He was elected a Fellow of the Royal Society (FRS) in 1983. The Royal Society awarded him the Gabor Medal in 1991 for molecular biology, in 1998 the Davy Medal for chemistry and in 2008 the Royal Medal. He is a Foreign Associate of the United States National Academy of Sciences, a Foreign Member of the American Philosophical Society, a Foreign Member of the Accademia dei Lincei, an Honorary Foreign Member of the American Academy of Arts and Sciences and a Fellow of the Academy of Medical Sciences.
His nomination for the Royal Society reads:
|“||Distinguished for work on mechanisms of enzyme catalysis, especially by stopped and quenched flow methods. He showed that a slow relaxation of chymotrypsin was not a chemical step on the reaction pathway, but a pH-dependent isomerization between active and inactive forms, and investigated the energetics and equilibria of the transition. He elucidated the leaving-group specificity, leading to a detailed structural interpretation which showed the energetics of "strain" at the binding site. Another experiment dispelled final doubts about the role of a tetrahedral intermediate. More recently Fersht has studied a more complex group of enzymes, the aminoacyl tRNA synthetases. He demonstrated that their precise specificity depends on consecutive independent recognition steps, and under appropriate conditions he trapped a transiently discharged aminoacyl tRNA. Fersht has shown how binding energy can be used to enhance either specificity or rate in an enzymatic reaction, leading to a demonstration of thermodynamic limitations on mechanisms of the "induced fit" type.||”|
Fersht has received many prizes and medals including: the FEBS Anniversary Prize; Novo Biotechnology Award; Charmian Medal of the Royal Society of Chemistry; Max Tishler Lecture and Prize Harvard University; The Datta Lectureship and Medal of the Federation of European Biochemical Societies; Jubilee Lecture and the Harden Medal of the Biochemical Society; Feldberg Foundation Prize, Distinguished Service Award, Miami Nature Biotechnology Winter Symposium; Christian B. Anfinsen Award of the Protein Society; Natural Products Award of the Royal Society of Chemistry, Stein and Moore Award of the Protein Society; Bader Award of the American Chemical Society; Kaj Ulrik Linderstrøm-Lang Prize and Medal; Johannes Martin Bijvoet Medal Utrecht University; and the Gilbert N. Lewis Medal University of California, Berkeley.
- List of publications from Google Scholar
- "EC/1983/09: Fersht, Alan Roy. Library and Archive Catalogue". London: The Royal Society. Archived from the original on 2014-05-13.
- "Professor Sir Alan Fersht FRS, Department of Chemistry, University of Cambridge". Retrieved 2011-07-26.
- Jackson, S. E.; Fersht, A. R. (1991). "Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition". Biochemistry 30 (43): 10428–10435. doi:10.1021/bi00107a010. PMID 1931967.
- Fersht, A. R.; Shi, J. P.; Knill-Jones, J.; Lowe, D. M.; Wilkinson, A. J.; Blow, D. M.; Brick, P.; Carter, P.; Waye, M. M. Y.; Winter, G. (1985). "Hydrogen bonding and biological specificity analysed by protein engineering". Nature 314 (6008): 235–238. doi:10.1038/314235a0. PMID 3845322.
- Matouschek, A.; Kellis, J. T.; Serrano, L.; Fersht, A. R. (1989). "Mapping the transition state and pathway of protein folding by protein engineering". Nature 340 (6229): 122–126. doi:10.1038/340122a0. PMID 2739734.
- Fersht, A.; Matouschek, A.; Serrano, L. (1992). "The folding of an enzyme I. Theory of protein engineering analysis of stability and pathway of protein folding". Journal of Molecular Biology 224 (3): 771–782. doi:10.1016/0022-2836(92)90561-W. PMID 1569556.
- Fersht, Alan (1999). Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding. San Francisco: W.H. Freeman. ISBN 0-7167-3268-8.
- Wilkinson, A. J. (2010). "The Selected Papers of Sir Alan Fersht: Development of Protein Engineering". Protein Engineering Design and Selection 24: 225. doi:10.1093/protein/gzq103.
- Qinghua Wang; Fersht, Alan (2010). Selected Papers of Sir Alan Fersht: The Development of Protein Engineering (Icp Selected Papers). River Edge, N.J: Imperial College Press. ISBN 1-84816-554-4.
- Fersht, Alan (1985). Enzyme structure and mechanism. San Francisco: W.H. Freeman. ISBN 0-7167-1614-3.
- "Professor Sir Alan Fersht FRS becomes the 42nd Master of Caius". Retrieved 2012-11-21.
- Europabio: profile[dead link]
- BBC: brief Fersht career summary at time of knighthood
- Imperial College London: biographical summary Alan Fersht
- Fersht webpage at MRC Laboratory of Molecular Biology, Cambridge UK
- Alan Fersht from the Scopus bibliographic database.
- "FERSHT, Sir Alan (Roy)". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
- Fersht, Alan Roy (1968). Intramolecular catalysis of ester hydrolysis (PhD thesis). University of Cambridge.(subscription required)
- "Alan R. Fersht receives Bader Award / Corey Award to David W. C. Mac Millan / Breslow Award to Peter B. Dervan". Angewandte Chemie International Edition 43 (41): 5430. 2004. doi:10.1002/anie.200462026. PMID 15484254.
- "Alan Fersht. 2001 Stein and Moore Award". Protein science : a publication of the Protein Society 10 (4): 905. 2001. PMID 11345067.
- Fersht, Alan (2007). Jaques Staunton Chess Sets 1849-1939. Kaissa Publications. ISBN 0-9557325-0-6.
Sir Christopher Hum
|Master of Gonville and Caius College,
University of Cambridge