Alan Lloyd Hodgkin
|Sir Alan Lloyd Hodgkin|
5 February 1914|
Banbury, England, UK
|Died||20 December 1998
Cambridge, England, UK
|Fields||Physiology and Biophysics|
|Alma mater||Trinity College, Cambridge|
|Notable awards||Nobel Prize in Physiology or Medicine (1963)|
|Children||Sarah, Deborah, Jonathan, and Rachel|
Sir Alan Lloyd Hodgkin, OM, KBE, PRS (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist, who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles.
Hodgkin was born in Banbury, Oxfordshire, to George Hodgkin and Mary Wilson Hodgkin. His father died of dysentery in Baghdad in 1918. His mother was remarried to Lionel Smith, with whom they lived. He was educated at The Downs School near Malvern, Gresham's School, and Trinity College, Cambridge. In 1930, he was the winner of a bronze medal in the Public Schools Essay Competition organized by the Royal Society for the Protection of Birds.
During the Second World War, he volunteered on Aviation Medicine at Farnborough and was subsequently transferred to the Telecommunications Research Establishment (TRE) where he worked on the development of centimetric radar, including the design of the Village Inn AGLT airborne gun-laying system. Earlier, in March 1941, Hodgkin had flown on the test flight of a Bristol Blenheim fitted with the first airborne centimetric radar system. As the war ended in 1945, he joined the faculty of physiology department in Cambridge University. He was the Foulerton Professor of the Royal Society between 1951 and 1969. He served on the Royal Society Council from 1958 to 1960 and on the Medical Research Council from 1959 to1963. He was foreign secretary of the Physiological Society from 1961 to 1967. He was appointed the John Humphrey Plummer Professor of Biophysics at Cambridge University in 1970. He also hold additional administrative posts such as Chancellor, University of Leicester, from 1971 to 1984, and Master, Trinity College, Cambridge, from 1978 to 1985.
With Andrew Fielding Huxley, Hodgkin worked on experimental measurements and developed an action potential theory representing one of the earliest applications of a technique of electrophysiology, known as the "voltage clamp". The second critical element of their research was the use of the giant axon of Atlantic squid (Loligo vulgaris), which enabled them to record ionic currents as they would not have been able to do in almost any other neuron, such cells being too small to study using the techniques of the time. The experiments started at the University of Cambridge, beginning in 1935 with frog sciatic nerve, and soon after they continued their work using squid giant axons at the Marine Biological Association Laboratory in Plymouth. In 1939, reporting work done in Plymouth, Alan Hodgkin and Andrew Huxley published a short paper in the journal Nature announcing their achievement of recording action potentials from inside a nerve fibre. Research was interrupted by World War II but after resuming their experimental work in Plymouth, the pair published their theory in 1952.
In 1963, with Huxley, he won the Nobel Prize in Physiology or Medicine for their work on the basis of nerve "action potentials", the electrical impulses which enable the activity of an organism to be coordinated by a central nervous system. Hodgkin and Huxley shared the prize that year with John Carew Eccles, who was cited for his research on synapses. Hodgkin and Huxley's findings led them to hypothesize ion channels, which were confirmed only decades later. Confirmation of ion channels came with the development of the patch clamp leading to a Nobel prize in 1991 for Erwin Neher and Bert Sakmann, and in 2003 for Roderick MacKinnon.
Alan Lloyd Hodgkin was knighted (KBE) in 1972 and appointed to the Order of Merit in 1973. He was elected President of the Marine Biological Association of the United Kingdom in 1966. From 1970 to 1975 he was President of the Royal Society. The Royal Society awarded him its Royal Medal in 1958 and Copley Medal in 1965. He was also elected to the American Association for the Advancement of Science, American Philosophical Society, American Academy of Arts and Sciences, Royal Danish Academy of Sciences and Letters, Deutsche Akademie, and Indian National Science Academy.
Alan Hodgkin married Marion Rous in 1944, whom she met while at Rockefeller Institute in 1938. She was the daughter of an American pathologist, Francis Peyton Rous, who won the 1966 Nobel Prize in Physiology or Medicine. She became Children's Book Editor at Macmillan Publishing Company and a successful writer of children's literature, including Young Winter's Tales and Dead Indeed. They had three daughters, Sarah, Deborah, and Rachel, and a son Jonathan. Jonathan Hodgkin became molecular biologist at Cambridge University. Deborah Hodgkin is also a successful psychologist.
- Huxley, S. A. (2000). "Sir Alan Lloyd Hodgkin, O.M., K.B.E. 5 February 1914 -- 20 December 1998: Elected F.R.S. 1948". Biographical Memoirs of Fellows of the Royal Society 46 (0): 219–241. doi:10.1098/rsbm.1999.0081.
- GRO Register of Births: MAR 1914 3a 2167 BANBURY – Alan L. Hodgkin, mmn = Wilson
- Benson, S. G. G., Crossley Evans, Martin, I Will Plant Me a Tree: an Illustrated History of Gresham's School (James & James, London, 2002) ISBN 0-907383-92-0
- Protection Of Birds Measures Urged By Royal Society in The Times, Saturday, Mar 29, 1930; pg. 14; Issue 45474; col C
- Hodgkin, A. L.; Huxley, A. F. (1939). "Action Potentials Recorded from Inside a Nerve Fibre". Nature 144 (3651): 710. Bibcode:1939Natur.144..710H. doi:10.1038/144710a0.
- Schwiening, C. J. (2012). "A brief historical perspective: Hodgkin and Huxley". The Journal of Physiology 590 (11): 2571–2575. doi:10.1113/jphysiol.2012.230458. PMID 22787170.
- Noble, D. (2010). "Biophysics and systems biology". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368 (1914): 1125–1139. doi:10.1098/rsta.2009.0245. PMC 3263808. PMID 20123750.
- "Alan L. Hodgkin". NNDB. Soylent Communications. Retrieved 5 March 2014.
- Lamb, Trevor (1999). "Obituary: Alan Hodgkin (1914-98)". Nature 397 (6715): 112–112. doi:10.1038/16362. PMID 9923671.
- The Master of Trinity at Trinity College, Cambridge
- Nobel biography of Hodgkin
- BBC obituary
- Speech at Nobel banquet, 1963
- Action Potential Paper
The Lord Butler of Saffron Walden
|Master of Trinity College, Cambridge
Sir Andrew Huxley
The Lord Adrian
|Chancellor of the University of Leicester
Sir George Porter