Between 1890 and 1893, he worked, together with his brother Silvestre de Palacio (engineer), on his most important project, the transporter bridge ("Puente Colgante") on the Nervion river, between Portugalete and Getxo (Biscay), for which he gained international recognition. It was the first bridge of this kind ever built.
All his work is characterized for the search of the functionality and the innovation, where iron and glass play a noticeable role. He passed long seasons of work in Madrid where he:
Participated in the construction of the Crystal Palace (inspired by the London one) in the same park, again with architect Ricardo Velázquez Bosco, coordinator of the project, and ceramicist Daniel Zuloaga (1887).