Aldehyde oxidase 1

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Aldehyde oxidase 1
Identifiers
Symbols AOX1 ; AO; AOH1
External IDs OMIM602841 MGI88035 HomoloGene68165 ChEMBL: 3257 GeneCards: AOX1 Gene
EC number 1.2.3.1
Orthologs
Species Human Mouse
Entrez 316 11761
Ensembl ENSG00000138356 ENSMUSG00000063558
UniProt Q06278 O54754
RefSeq (mRNA) NM_001159 NM_009676
RefSeq (protein) NP_001150 NP_033806
Location (UCSC) Chr 2:
201.45 – 201.54 Mb
Chr 1:
58.03 – 58.11 Mb
PubMed search [1] [2]

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.[1][2]

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.[1]

Clinical significance[edit]

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.[2]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: aldehyde oxidase 1". 
  2. ^ a b Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D (March 1995). "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. doi:10.1007/BF02255787. PMID 7570184. 

Further reading[edit]