Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

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Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Identifiers
Symbol Ald_Xan_dh_C
Pfam PF01315
InterPro IPR000674
SCOP 1alo
SUPERFAMILY 1alo

The aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain is an evolutionary conserved protein domain.

Aldehyde oxidase (EC 1.2.3.1) catalyzes the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase (EC 1.1.1.204) catalyzes the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase (EC 1.1.3.22) activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulfhydryl groups.

Human proteins containing this domain[edit]

Further reading[edit]

This article incorporates text from the public domain Pfam and InterPro IPR000674