It starts at Bayshore Boulevard near the Alemany Maze (the intersection of Interstate 280 and U.S. 101). The eastbound and westbound lanes split beneath the interchange, allowing for access ramps to US-101 from the middle. This configuration is referred to as the Alemany Circle. To the west, the road again splits into two carriageways, with I-280 running in the middle. At Congdon Street, the two carriageways merge. After passing under Mission Street, Alemany continues south and traverses the Excelsior District, running south of I280. Between Brotherhood Boulevard and San Jose Avenue, Alemany runs one-way eastbound, with westbound traffic crossing under 280 and through Sagamore Street, meeting up with Alemany again. It continues west and ends at Junipero Serra Boulevard (State Route 1), which provides access to John Daly Boulevard and I-280.