|Systematic (IUPAC) name|
|Bioavailability||The alfaxalone molecule is solubilised in the Alfaxan formulation using 2α- hydroxypropyl β cyclodextrin. Cyclodextrins are complex polysaccharides derived from starch that supply a hydrophobic centre for lipophilic drugs like alfaxalone.|
|Mol. mass||332.477 g/mol|
|(what is this?)|
It is one of the constituents of althesin.
It is used in veterinary practice under the tradename Alfaxan. 
It is licensed for use in both dogs and cats.
Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.
A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors. 
Alfaxalone is metabolised rapidly in the liver. Alfaxalone has a very short plasma elimination half-life in dogs and cats.
- "Alfaxalone". Drugs.com.
- Harrison, N. L.; Vicini, S.; Barker, J. L. (1987). "A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons" (pdf). The Journal of neuroscience 7 (2): 604–609. PMID 3819824.
- Mihic, S. J.; Whiting, P. J.; Klein, R. L.; Wafford, K. A.; Harris, R. A. (1994). "A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy" (pdf). The Journal of Biological Chemistry 269 (52): 32768–32773. PMID 7806498.
|This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.|