Alimemazine
From Wikipedia, the free encyclopedia
 |
|
|---|---|
 |
|
| Systematic (IUPAC) name | |
| N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a600010 |
| Pregnancy cat. | C (AU) |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Half-life | 4.78 ± 0.59 hours[1] |
| Identifiers | |
| CAS number | 84-96-8  |
| ATC code | D04AA10 R06AD02, R06AD05 |
| PubChem | CID 5574 |
| DrugBank | APRD00258 |
| ChemSpider | 5373 |
| UNII | 76H78MJJ52 |
| KEGG | D07125 |
| ChEMBL | CHEMBL829 |
| Chemical data | |
| Formula | C18H22N2S |
| Mol. mass | 298.447 g/mol |
| SMILES | eMolecules & PubChem |
|
|
 (what is this?) (verify) |
|
Alimemazine (INN), also known as trimeprazine (former BAN and USAN; brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).[2] It also acts as a sedative, hypnotic and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic treatment.[3]
In veterinary use, the combination of alimemazine and prednisolone is licensed as an antipruritic and antitussive in dogs.
[edit] References
- ^ Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology 38 (3): 172–6. PMID 2871150.
- ^ "PubChem CID 78032". http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=78032.
- ^ "Drugbank:Trimeprazine". http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00258.txt.
|
||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||
