Alison was born in Exeter, England) and educated at Blundell's School. She fell in love with radio at Exeter University, presenting on the uni's own station URE . She claimed her entire career had been an accident (having studied French and Philosophy) as it was the DJ on URE she fancied first, not the show. Alison's first job with the BBC was with the now-defunct BBC Dorset FM, which is now part of BBC Radio Solent . When her first husband moved the family to Oxfordshire, she talked her way into BBC Radio Oxford .
She worked there for over ten years.
Alison has two children by her first husband, David Booker; Joanne and Douglas Booker. 20 and 19 respectively. Alison made a life and a home in Wantage, Oxfordshire where the children attended the local schools and continue to live.
Alison was diagnosed with breast cancer in 2002. After a double mastectomy, radio- and chemotherapy she returned to her Afternoon Show on BBC Radio Oxford. She tackled it with her usual sense of humour, once joking to a doctor who needed to examine her that she didn't take her clothes off for anything less than a couple of really good meals and a bunch of flowers. Alison's breast cancer returned in her lungs in February 2006.
Alison retired from the BBC in January 2007. After a year at home, and bored with just waiting to die, she accidentally got freelance work at the then recently launched 106 Jack FM  . She went full-time in September 2008.
In 2009 Ali started documenting her life with cancer via audio diaries which were broadcast on 106 Jack FM (Oxfordshire)  In May 2010 Ali was awarded the Silver Sony award. A few weeks later the diaries also won Ali commercial radio’s top award – a Radio Academy Gold Arqiva. Ali's diaries were featured in The Sunday Times on 27.6.2010 and The Independent on 1.7.2010. MP Ed Vaizey also paid tribute to Ali in the House of Commons on 24.6.2010. Her diaries are available in iTunes or via Podomatic (AlisDiaries).
Alison died on July 1, 2010, of breast cancer. She died peacefully, surrounded by the family she loved at Sobell House Hospice in Oxfordshire, a place she loved.
On September 24, 2010 Ali's Cancer Diaries was awarded the Silver World Medal at The New York Festival Radio Awards in the Social Issues/Current Events Category.