Alitame

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Alitame
Alitame.png
Identifiers
CAS number 80863-62-3 N
PubChem 64763
ChemSpider 58297 YesY
UNII 6KI9M51JOG YesY
ChEMBL CHEMBL2104004 N
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C14H25N3O4S
Molar mass 331.431
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Alitame is an artificial sweetener developed by Pfizer in the early 1980s and currently marketed in some countries under the brand name Aclame.[1] Like aspartame, alitame is an aspartic acid-containing dipeptide. Most dipeptides are not sweet, but the unexpected discovery of aspartame in 1965 led to a search for similar compounds that shared its sweetness. Alitame is one such second-generation dipeptide sweetener. Neotame, developed by the owners of the NutraSweet brand, is another.

Alitame has several distinct advantages over aspartame. It is about 2000 times sweeter than sucrose,[2] about 10 times sweeter than aspartame, and has no aftertaste. Its half-life under hot or acidic conditions is about twice as long as aspartame's, although some other artificial sweeteners, including saccharin and acesulfame potassium, are more stable yet. Unlike aspartame, alitame does not contain phenylalanine, and can therefore be used by people with phenylketonuria.

Alitame has approved for use in Mexico, Australia, New Zealand and China. Danisco has withdrawn its petition for using alitame as a sweetening agent or flavoring in food in USA.[3]

Synthesis[edit]

Alitame synthesis: U.S. Patent 5,874,121 C.f. Lednicer book 6.

References[edit]

  1. ^ Ellis, J. W. (1995). "Overview of Sweeteners". Journal of Chemical Education 72 (8): 671–675. doi:10.1021/ed072p671. 
  2. ^ Laura Halpin Rinsky; Glenn Rinsky (2009). The Pastry Chef's Companion: A Comprehensive Resource Guide for the Baking and Pastry Professional. Chichester: John Wiley & Sons. p. 5. ISBN 0-470-00955-1. OCLC 173182689. 
  3. ^ "Notice of withdrawal of petition: docket No. FDA-1986-F-0277 (formerly docket No. 1986F-0364)" (pdf). Food and Drug Administration.