Allan C. Spradling
|Allan C. Spradling|
|Born||1949 (age 64–65)|
|Institutions||Carnegie Institution for Science, Howard Hughes Medical Institute|
|Alma mater||University of Chicago, Massachusetts Institute of Technology|
|Notable awards||George W. Beadle Award (2003)|
Allan C. Spradling is an American scientist and principal investigator at the Carnegie Institution for Science and the Howard Hughes Medical Institute who studies egg development in the model organism, Drosophila melanogaster, a fruit fly. He is considered a leading researcher in the developmental genetics of the fruit fly egg and has developed a number of techniques in his career that have led to greater understanding of fruit fly genetics including contributions to sequencing its genome. He is also an adjunct professor at Johns Hopkins University and at the Johns Hopkins University School of Medicine.
Spradling and American fellow American geneticist Gerald M. Rubin are considered pioneers in the field of genetics for their work in the early 1980s with their idea to "attach" a gene to a Drosophila transposon, P elements, known to insert itself into fruit fly's chromosomes. From this research came work from other scientists on transposons as a tool for genetic alterations in organisms.
In 2003 Spradling was awarded the Beadle Medal and in 2008 Spradling was awarded the Gruber Prize in Genetics for his work on the Drosophila genome and continues his work in investigating novel technological approaches to genetics, egg development and stem cells.
- Orr-Weaver, T. (2003). "The 2003 George W. Beadle Medal; Gerald M. Rubin and Allan C. Spradling". Genetics 164 (4): 1248–1249. PMC 1462668. PMID 15106662.
- "Howard Hughes Medical Institute Investigators: Allan C. Spradling, Ph.D.". Retrieved 2009-10-25.
- Spradling, A.; Rubin, G. (1982). "Transposition of cloned P elements into Drosophila germ line chromosomes". Science 218 (4570): 341–347. Bibcode:1982Sci...218..341S. doi:10.1126/science.6289435. PMID 6289435.
- Jedicke, Peter (2001). Extreme science: transplanting your head and other feats of the future. New York: St. Martin's Griffin. ISBN 978-0-312-26819-0.
- Rubin, G.; Spradling, A. (1982). "Genetic transformation of Drosophila with transposable element vectors". Science 218 (4570): 348–353. Bibcode:1982Sci...218..348R. doi:10.1126/science.6289436. PMID 6289436.
- Spradling, A.; Drummond-Barbosa, D.; Kai, T. (2001). "Stem cells find their niche". Nature 414 (6859): 98–104. doi:10.1038/35102160. PMID 11689954.
- Spradling, A.; Stern, D.; Beaton, A.; Rhem, E.; Laverty, T.; Mozden, N.; Misra, S.; Rubin, G. (1999). "The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes". Genetics 153 (1): 135–177. PMC 1460730. PMID 10471706.