Allan Wilson

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For other people named Allan Wilson, see Allan Wilson (disambiguation).
Allan Wilson
Allan C Wilson.png
Born Allan Charles Wilson
(1934-10-18)18 October 1934
Ngaruawahia, New Zealand
Died 21 July 1991(1991-07-21) (aged 56)
Seattle, US
Citizenship New Zealand
Fields Zoology
Biochemistry
Institutions University of California, Berkeley
Alma mater University of Otago
University of California, Berkeley
Doctoral advisor Arthur Pardee
Other academic advisors Nathan O. Kaplan
Notable students Svante Pääbo
Mary-Claire King
Vincent Sarich
Rebecca L. Cann
Known for Molecular clock
Mitochondrial Eve
Notable awards MacArthur Fellowship
ForMemRS

Allan Charles Wilson (18 October 1934 – 21 July 1991) was a Professor of Biochemistry at the University of California, Berkeley, a pioneer in the use of molecular approaches to understand evolutionary change and reconstruct phylogenies, and a revolutionary contributor to the study of human evolution. He was one of the most controversial figures in post-war biology; his work attracted a great deal of attention both from within and outside the academic world. He is the only New Zealander to have won the MacArthur Fellowship.[1]

He is best known for experimental demonstration of the concept of the molecular clock (with his doctoral student Vincent Sarich), which was theoretically postulated by Linus Pauling and Emile Zuckerkandl, revolutionary insights into the nature of the molecular anthropology of higher primates and human evolution, called Mitochondrial Eve hypothesis (with his doctoral students Rebecca L. Cann and Mark Stoneking).[2][3]

Early life and education[edit]

Allan Wilson was born in Ngaruawahia, New Zealand, and raised on his family's rural dairy farm at Helvetia, Pukekohe, about twenty miles south of Auckland. At his local Sunday School, the vicar's wife was impressed by young Allan's interest in evolution and encouraged Allan's mother to enroll him at the elite King's College secondary school in Auckland. There he excelled in mathematics, chemistry, and sports. Wilson already had an interest in evolution and biochemistry, but intended to be the first in his family to attend university by pursuing studies in agriculture and animal science. Wilson met Professor Campbell Percy McMeekan, a New Zealand pioneer in animal science, who suggested that Wilson attend the University of Otago in southern New Zealand to further his study in biochemistry rather than veterinary science.[4] Wilson gained a BSc from the University of Otago in 1955, majoring in both zoology and biochemistry. The bird physiologist Donald S. Farner met Wilson as an undergraduate at Otago and invited him to Washington State University at Pullman as his graduate student. Wilson obliged and completed a master's degree in zoology at WSU under Farner in 1957, where he worked on the effects of photoperiod on the physiology of birds.[5][6]

Wilson then moved to the University of California, Berkeley, to pursue his doctoral research. At the time the family thought Allan would only be gone two years. Instead, Wilson remained in the United States, gaining his PhD at Berkeley in 1961 under the direction of biochemist Arthur Pardee for work on the regulation of flavin biosynthesis in bacteria.[7] From 1961 to 1964, Wilson studied as a post-doc under biochemist Nathan O. Kaplan at Brandeis University in Waltham, Massachusetts.[8] In Kaplan's lab, working with lactate and malate dehydrogenases,[9] Wilson was first introduced to the nascent field of molecular evolution.[10][11][12] Nate Kaplan was one of the very earliest pioneers to address phylogenetic problems with evidence from protein molecules,[13][14] an approach that Wilson later famously applied to human evolution and primate relationships. After Brandeis, Wilson returned to Berkeley where he set up his own lab in the Biochemistry department, remaining there for the rest of his life.[5][15]

Career and scientific contributions[edit]

Wilson joined the UC Berkeley faculty of biochemistry in 1964, and was promoted to full professor in 1972.[8] His first major scientific contribution was published as Immunological Time-Scale For Hominid Evolution in the journal Science in December 1967.[16] With his student Vincent Sarich,[17][18] he showed that evolutionary relationships of the human species with other primates, in particular the Great Apes (chimpanzees, gorillas, and orangutans), could be inferred from molecular evidence obtained from living species, rather than solely from fossils of extinct creatures. Their microcomplement fixation method (see complement system) measured the strength of the immune reaction between an antigen (serum albumin) from one species and an antibody raised against the same antigen in another species. The strength of the antibody-antigen reaction was known to be stronger between more closely related species: their innovation was to measure it quantitatively among many species pairs as an "immunological distance". When these distances were plotted against the divergence times of species pair with well-established evolutionary histories, the data showed that the molecular difference increased linearly with time, in what was termed a "molecular clock". Given this calibration curve, the time of divergence between species pairs with unknown or uncertain fossil histories could be inferred. Most controversially, their data suggested that divergence times between humans, chimpanzees, and gorillas were on the order of 3~5 million years, far less than the estimates of 9~30 million years accepted by conventional paleoanthropologists from fossil hominids such as Ramapithecus. This 'recent origin' theory of human/ape divergence remained controversial until the discovery of the "Lucy" fossils in 1974.[15]

Wilson and another PhD student Mary-Claire King subsequently compared several lines of genetic evidence (immunology, amino acid differences, and protein electrophoresis) on the divergence of humans and chimpanzees, and showed that all methods agreed that the two species were >99% similar.[4][19] Given the large organismal differences between the two species in the absence of large genetic differences, King and Wilson argued that it was not structural gene differences that were responsible for species differences, but gene regulation of those differences, that is, the timing and manner in which near-identical gene products are assembled during embryology and development. In combination with the "molecular clock" hypothesis, this contrasted sharply with the accepted view that larger or smaller organismal differences were due to large or smaller rates of genetic divergence.

In the early 1980s, Wilson further refined traditional anthropological thinking with his work with PhD students Rebecca Cann and Mark Stoneking on the so-called "Mitochondrial Eve" hypothesis.[20] In his efforts to identify informative genetic markers for tracking human evolutionary history, he focused on mitochondrial DNA (mtDNA) — genes that are found in mitochondria in the cytoplasm of the cell outside the nucleus. Because of its location in the cytoplasm, mtDNA is passed exclusively from mother to child, the father making no contribution, and in the absence of genetic recombination defines female lineages over evolutionary timescales. Because it also mutates rapidly, it is possible to measure the small genetic differences between individual within species by restriction endonuclease gene mapping. Wilson, Cann, and Stoneking measured differences among many individuals from different human continental groups, and found that humans from Africa showed the greatest inter-individual differences, consistent with an African origin of the human species (the so-called "Out of Africa" hypothesis). The data further indicated that all living humans shared a common maternal ancestor, who lived in Africa only a few hundreds of thousands of years ago. This common ancestor became widely known in the media and popular culture as the Mitochondrial Eve. This had the unfortunate and erroneous implication that only a single female lived at that time, when in fact the occurrence of a coalescent ancestor is a necessary consequence of population genetic theory, and the Mitochondrial Eve would have been only one of many humans (male and female) alive at that time.[2][3] This finding was, like his earlier results, not readily accepted by anthropologists. Conventional hypothesis was that various human continental groups had evolved from diverse ancestors, over several million of years since divergence from chimpanzees. The mtDNA data, however, strongly suggested that all humans descended from a common, quite recent, African mother.[4][15]

Death and legacy[edit]

Wilson became ill with leukemia, and after a bone marrow transplant, died on Sunday, 21 July 1991, at the Fred Hutchinson Memorial Cancer Research Center in Seattle. He had been scheduled to give the keynote address at an international conference the same day. He was 56, at the height of his scientific recognition and powers.[3][5][21] He is survived by his wife, Leona Wilson (died in 2009), and two children, Ruth (born 1961), of East Lansing, Michigan, and David (born 1964), of San Francisco.[8][1]

Wilson's success can be attributed to his strong interest and depth of knowledge in biochemistry and evolutionary biology, his insistence of quantification of evolutionary phenomena, and has early recognition of new molecular techniques that could shed light on questions of evolutionary biology. After development of quantitative immunological methods, his lab was the first to recognize restriction endonuclease mapping analysis as a quantitative evolutionary genetic method, which led to his early use of DNA sequencing, and the then-nascent technique of PCR to obtain large DNA sets for genetic analysis of populations. He trained scores of undergraduate, graduate (34 people, 17 each of men and women, received their doctoral degrees in his lab), and post-doctoral students in molecular evolutionary biology, including sabbatical visitors from six continents. His lab published more than 300 technical papers, and was recognized as a mecca for those wishing to enter the field of molecular evolution in the 1970s and 1980s.[6]

The Allan Wilson Centre for Molecular Ecology and Evolution was established in 2002 in his honour to advance knowledge of the evolution and ecology of New Zealand and Pacific plant and animal life, and human history in the Pacific. The Centre is under the Massey University, at Palmerston North, New Zealand, and is a national collaboration involving the University of Auckland, Victoria University of Wellington, the University of Otago, University of Canterbury and the New Zealand Institute for Plant and Food Research.[22]

A 41-minutes documentary film of his life entitled Allan Wilson, Evolutionary: Biochemist, Biologist, Giant of Molecular Biology was released by Films Media Group in 2008.[23]

Awards and honours[edit]

References[edit]

  1. ^ a b Cann, R. L. (9 July 2014). "Allan Charles Wilson. 18 October 1934 -- 21 July 1991". Biographical Memoirs of Fellows of the Royal Society. doi:10.1098/rsbm.2013.0006. 
  2. ^ a b Matisoo-Smith E, Matisoo-Smith L, Horsburgh KA (2012). DNA for Archaeologists. California, US: Left Coast Press, Inc. pp. 14–16. ISBN 978-1-59874-681-5. 
  3. ^ a b c Cann RL (1993). "Obituary: Allan C. Wilson, 1935-1991". Human Biology 65 (3): 343–358. PMID 8319940. 
  4. ^ a b c Chaterjee S (2009). Global Encyclopaedia Of Evolutionary Biology Vol 1. New Delhi, India: Global Vision Publishing House. pp. 470–471. ISBN 9788182202160. 
  5. ^ a b c Ames BN, Jukes TH, Sarich VM, Wake DB (1991). "Allan Charles Wilson, Biochemistry; Molecular Biology: Berkeley". Calisphere (University of California). The Regents of The University of California. Retrieved 2013-05-01. 
  6. ^ a b King MC (1992). "Allan C. Wilson (1934-1991): In Memoriam". American Journal of Human Genetics 50 (1): 234–235. PMC 1682534. 
  7. ^ Wilson, A. C.; Pardee, A. B. (1962). "Regulation of flavin synthesis by Escherichia coli". Journal of general microbiology 28: 283–303. doi:10.1099/00221287-28-2-283. PMID 14007303. 
  8. ^ a b c Sanders R (22 July 1991). "Berkeley's Allan C. Wilson, the world authority on 'molecular evolution,' is dead at 56". UC Berkeley News. University of California, Berkeley. Retrieved 2013-05-01. 
  9. ^ Wilson, A. C.; Cahn, R. D.; Kaplan, N. O. (1963). "Functions of the two forms of lactic dehydrogenase in the breast muscle of birds". Nature 197: 331–334. doi:10.1038/197331a0. PMID 14000995. 
  10. ^ Wilson, A. C.; Kaplan, N. O.; Levine, L.; Pesce, A.; Reichlin, M.; Allison, W. S. (1964). "Evolution of Lactic Dehydrogenases". Federation proceedings 23: 1258–1266. PMID 14236134.  edit
  11. ^ A.C.Wilson and N.O.Kaplan (1963) Enzymes and nucleic acids in systematics. Proceedings of the XVI International Congress of Zoology Vol.4, pp.125-127.
  12. ^ A.C. Wilson and N.O. Kaplan (1964) Enzyme structure and its relation to taxonomy. In: C.A.Leone (editor) Taxonomic Biochemistry and Serology Ronald Press, New York.
  13. ^ Kaplan, N. O.; Ciotti, M. M.; Hamolsky, M.; Bieber, R. E. (1960). "Molecular heterogeneity and evolution of enzymes". Science 131 (3398): 392–397. doi:10.1126/science.131.3398.392 (inactive 2014-08-12). PMID 14404414. 
  14. ^ Kaplan, N. O.; Ciotti, M. M. (1961). "Evolution and differentiation of dehvdrogenases". Annals of the New York Academy of Sciences 94: 701–722. PMID 14037006. 
  15. ^ a b c Haviland WA, Walrath D, Prins HEL, McBride B (2011). Evolution and Prehistory: The Human Challenge (9 ed.). California, US: Wadsworth Cengage Learning. pp. 129–130. ISBN 978-0-495-81219-7. 
  16. ^ Sarich, V. M.; Wilson, A. C. (1967). "Immunological time scale for hominid evolution". Science 158 (3805): 1200–1203. doi:10.1126/science.158.3805.1200. PMID 4964406. 
  17. ^ Ward, Stanley Paul (15 November 1999). "Allan Wilson Revolutionary Evolutionist". nzedge.com. Retrieved 10 July 2014. 
  18. ^ Chaterjee, Somya (2009). Global Encyclopaedia Of Evolutionary Biology (2 Vol. Set). New Delhi (India): Global Vision Pub House. pp. 470–471. ISBN 9788182202160. 
  19. ^ King, M.; Wilson, A. (1975). "Evolution at two levels in humans and chimpanzees". Science 188 (4184): 107–116. doi:10.1126/science.1090005. PMID 1090005. 
  20. ^ Cann, R. L.; Stoneking, M.; Wilson, A. C. (1987). "Mitochondrial DNA and human evolution". Nature 325 (6099): 31–36. doi:10.1038/325031a0. PMID 3025745. 
  21. ^ Felsenstein J (1991). "Obituary: Allan Charles Wilson (1934–1991)". Nature 353 (6339): 19. doi:10.1038/353019a0. 
  22. ^ Allan Wilson Centre. "About us: Allan Wilson Centre for Molecular Ecology and Evolution". Allan Wilson Centre for Molecular Ecology and Evolution. Retrieved 2013-05-01. 
  23. ^ O'Toole E (30 June 2009). "Allan Wilson, Evolutionary: Biochemist, Biologist, Giant of Molecular Biology". Allan Wilson Centre for Molecular Ecology and Evolution. Films Media Group, New Jersey, US. Retrieved 2013-05-01. 

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