Allotopic expression
From Wikipedia, the free encyclopedia
Allotopic expression (AE) refers to expression from the nuclear genome of genes that normally are expressed only from the mitochondrial genome. Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases (de Grey 2000), however this view is controversial (Oca-Cossio et al. 2003).
[edit] References
- de Grey AD (September 2000). "Mitochondrial gene therapy: an arena for the biomedical use of inteins". Trends Biotechnol. 18 (9): 394–9. doi:10.1016/S0167-7799(00)01476-1. PMID 10942964. http://linkinghub.elsevier.com/retrieve/pii/S0167-7799(00)01476-1.
- Oca-Cossio J, Kenyon L, Hao H, Moraes CT (October 2003). "Limitations of allotopic expression of mitochondrial genes in mammalian cells". Genetics 165 (2): 707–20. PMC 1462783. PMID 14573482. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1462783.
