Allylglycine

Allylglycine
	IUPAC name 2-Aminopent-4-enoic acid
Identifiers
CAS number	7685-44-1
PubChem	14044
ChemSpider	13425
Jmol-3D images	Image 1; Image 2
	SMILES C=CCC(C(=O)O)N O=C(O)C(N)CC=C ;
	InChI InChI=1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8) ; Key: WNNNWFKQCKFSDK-UHFFFAOYSA-N InChI=1/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8); Key: WNNNWFKQCKFSDK-UHFFFAOYAL ;
Properties
Molecular formula	C5H9NO2
Molar mass	115.13 g/mol
Appearance	white crystalline powder
Density	1.098 g/mL
Melting point	265 °C, 538 K, 509 °F
Boiling point	231 °C, 504 K, 448 °F
Hazards
Main hazards	Irritant
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

Allylglycine is a glycine derivative. It is an inhibitor of the enzyme glutamate decarboxylase.^[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.^[2] It is used to induce convulsions in animals in scientific studies.^{[citation needed]}

References [edit]

^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383.
^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford) 22 (6): 633–41. doi:10.1177/0269881107082902. PMID 18308797.

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