There is no standard treatment for alopecia universalis. Spontaneous regrowth is always a possibility, even for those with 100% hair loss over many years. However, it is not possible to predict when regrowth will occur.[unreliable medical source?] Many treatments have been explored, including immunomodulatory agents such as imiquimod.Tofacitinib citrate may also have benefits. In June 2014, it was reported that a 25-year-old man with almost no hair on his body grew a full head of hair, and eyebrows, eyelashes, facial, armpit and other hair, following 8 months of treatment.