alpha-Aminoadipic acid

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α-Aminoadipic acid
Alpha-aminoadipic acid.svg
IUPAC name
2-aminohexanedioic acid
542-32-5 N
ChEBI CHEBI:37024 YesY
ChEMBL ChEMBL433238 YesY
ChemSpider 456 YesY
Jmol-3D images Image
MeSH 2-Aminoadipic+Acid
PubChem 469
Molar mass 161.156 g/mol
Appearance Crystalline
Density 1.333 g/mL
Melting point 196 °C (385 °F; 469 K)
Boiling point 364 °C (687 °F; 637 K)
Main hazards Irritant
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

α-Aminoadipic acid is an intermediate in the α-Aminoadipic acid pathway for the metabolism of lysine and saccharopine. It is synthesised from homoisocitrate by aminoadipate aminotransferase and reduced by aminoadipate reductase to form the semialdehyde.

A 2013 study identified α-Aminoadipic acid (2-aminoadipic acid) as a novel predictor of the development of diabetes and suggested that it is a potential modulator of glucose homeostasis in humans.[1]

See also[edit]


  1. ^ Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE (2013). "2-Aminoadipic acid is a biomarker for diabetes risk". J Clin Invest 123 (10): 4309–4317. doi:10.1172/JCI64801. PMC 3784523. PMID 24091325.