alpha-Pyrrolidinopentiophenone

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alpha-Pyrrolidinopentiophenone
Alpha-Pyrrolidinopentiophenone.svg
A-PVP.png
Systematic (IUPAC) name
(RS)-1-phenyl-2-(1-pyrrolidinyl)-1-pentanone
Clinical data
Legal status
  • UK: Class B
  • US: Schedule 1
Routes oral, intranasal, vaporization, intravenous, rectal, sublingual
Identifiers
CAS number 14530-33-7 YesY
5485-65-4 (HCl)
ATC code ?
PubChem CID 11148955
ChemSpider 9324063 YesY
ChEMBL CHEMBL205082 YesY
Chemical data
Formula C15H21NO 
Mol. mass 231.333 g/mol
 YesY (what is this?)  (verify)

α-Pyrrolidinopentiophenone (alpha-pyrrolidinovalerophenone, α-PVP, alpha-PVP, O-2387, β-ketone-prolintane, Prolintanone) is a stimulant compound developed in the 1960s and related to pyrovalerone and is the ketone analog of prolintane.[1]

The mechanism of action is unknown for α-pyrrolidinopentiophenone. α-PVP is believed to act similarly to the designer drug MDPV, which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), although no substantial research on this compound has been conducted.

α-PVP is a Schedule I drug in New Mexico, Delaware, Oklahoma, and Virginia. On January 28, 2014, the DEA listed it, along with 9 other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[2] The Drug was explicitly made illegal in New South Wales after it was illegally marketed with the imprimatur of erroneous legal advice that it was not encompassed by analog provisions of the relevant act. It is encompassed by those provisions, and therefore has been illegal for many years in New South Wales. The legislative action followed the death of two individuals from using it; one jumping off a balcony, another having a heart attack after a state of delirium. It is sometimes the active ingredient in a drug often referred to colloquially as "bath salts".[3]

See also[edit]

References[edit]

  1. ^ Sauer, C.; Peters, F. T.; Haas, C.; Meyer, M. R.; Fritschi, G.; Maurer, H. H. (2009). "New Designer Drug α-Pyrrolidinovalerophenone (PVP): Studies on its Metabolism and Toxicological Detection in Rat Urine Using Gas Chromatographic / Mass Spectrometric Techniques". Journal of Mass Spectrometry 44 (6): 952–964. doi:10.1002/jms.1571. PMID 19241365.  edit
  2. ^ "2014 Rules, DEA/DOJ Diversion Control". 
  3. ^ Olding, Rachel. "'Bath salts' death: lethal drug was a top seller". The Sydney Morning Herald.