|Molar mass||278.43 g/mol|
|Melting point||48 °C (118 °F; 321 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
α-Eleostearic acid or (9Z,11E,13E)-octadeca-9,11,13-trienoic acid, is an organic compound, a conjugated fatty acid and one of the isomers of octadecatrienoic acid. It is often called simply eleostearic acid although there is also a β-eleostearic acid (the all-trans or (9E,11E,13E) isomer)
In their pioneering work on essential fatty acids, Burr, Burr and Miller compared the nutritional properties of α-eleostearic acid (ELA) to that of its isomer alpha-linolenic acid (ALA). ALA relieved essential fatty acid deficiency; ELA did not.
In rats, α-eleostearic acid is converted to a conjugated linoleic acid. The compound has been found to induce programmed cell death of fat cells, and of HL60 leukemia cells in vitro at a concentration of 20 μM. Diets containing 0.01% bitter gourd seed oil (0.006% as α-eleostearic acid) were found to prevent azoxymethane-induced colon carcinogenesis in rats.
15,16-Dihydroxy α-eleostearic acid
- Burr, G.O.; Burr, M.M.; Miller, E. (1932). "On the nature and role of the fatty acids essential in nutrition" (PDF). J. Biol. Chem. 97 (1): 1–9. Retrieved 2007-01-17.
- Tsuzuki T, Kawakami Y, Abe R et al. (1 August 2006). "Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid". J Nutr 136 (8): 2153–9. PMID 16857834. Retrieved 2007-01-17.
- Nishimura K, Tsumagari H, Morioka A, Yamauchi Y, Miyashita K, Lu S, Jisaka M, Nagaya T, Yokota K (2002). "Regulation of apoptosis through arachidonate cascade in mammalian cells". Appl Biochem Biotechnol. 102-103 (1-6): 239–50. doi:10.1385/ABAB:102-103:1-6:239. PMID 12396127.
- Masuko Kobori, Mayumi Ohnishi-Kameyama, Yukari Akimoto, Chizuko Yukizaki and Mitsuru Yoshida (2008) α-Eleostearic Acid and Its Dihydroxy Derivative Are Major Apoptosis-Inducing Components of Bitter Gourd. Journal of Agricultural and Food Chemistry, volume 56, issue 22, pages 10515–10520. doi:10.1021/jf8020877
- H. Kohno, Y. Yasui, R. Suzuki, M. Hosokawa, K. Miyashita, T. Tanaka (2004), Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPAR γ expression and alteration of lipid composition. International Journal of Cancer, volume 110, pages 896–901.