Alpha-enolase

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Enolase 1, (alpha)
Protein ENO1 PDB 2PSN.png
Rendering based on PDB 2PSN.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ENO1 ; ENO1L1; MPB1; NNE; PPH
External IDs OMIM172430 MGI95393 HomoloGene68183 ChEMBL: 3298 GeneCards: ENO1 Gene
EC number 4.2.1.11
RNA expression pattern
PBB GE ENO1 201231 s at tn.png
PBB GE EDARADD 217294 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2023 13806
Ensembl ENSG00000074800 ENSMUSG00000059040
UniProt P06733 P17182
RefSeq (mRNA) NM_001201483 NM_023119
RefSeq (protein) NP_001188412 NP_075608
Location (UCSC) Chr 1:
8.92 – 8.94 Mb
Chr 18:
48.05 – 48.05 Mb
PubMed search [1] [2]

Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.

Relationship to Myc-binding protein-1[edit]

Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene.[1] Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

Clinical significance[edit]

Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy.[2] Single studies have also identified it as an autoantigen associated with severe asthma[3] and a putative target antigen of anti-endothelial cell antibody in Behçet's disease.[4] Reduced expression of the enzyme has been found in the corneal epithelium of people suffering from keratoconus.[5][6]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

Interactions[edit]

Alpha-enolase has been shown to interact with TRAPPC2.[7]

See also[edit]

External links[edit]

References[edit]

  1. ^ Subramanian A, Miller DM. (2000) Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000 Feb 25;275(8):5958-65. PMID 10681589 free full text
  2. ^ Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M. High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy. J Neuroimmunol. 2007 Apr;185(1-2):195-200. Epub 2007 Mar 1. PMID 17335908
  3. ^ Nahm DH, Lee KH, Shin JY, Ye YM, Kang Y, Park HS. (2006) Identification of alpha-enolase as an autoantigen associated with severe asthma. J Allergy Clin Immunol. 2006 Aug;118(2):376-81. Epub 2006 Jun 9. PMID 16890761 doi:10.1016/j.jaci.2006.04.002
  4. ^ Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D (2003) Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibodies in Behcet's disease. Arthritis Rheum 2003, 48:2025-2035. PMID 12847697 free full text
  5. ^ Srivastava OP, Chandrasekaran D, Pfister RR. Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas. Mol Vis. 2006 Dec 20;12:1615-25. PMID 17200661 free full text
  6. ^ Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. Exp Eye Res 2006; 82:201-9. PMID 16083875
  7. ^ Ghosh, A K; Majumder M; Steele R; White R A; Ray R B (January 2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. (UNITED STATES) 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. ISSN 0270-7306. PMC 86643. PMID 11134351.