Alpha 2-antiplasmin

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Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
2R9Y.png
Identifiers
Symbols SERPINF2 ; A2AP; AAP; ALPHA-2-PI; API; PLI
External IDs OMIM613168 MGI107173 HomoloGene719 GeneCards: SERPINF2 Gene
RNA expression pattern
PBB GE SERPINF2 205075 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5345 18816
Ensembl ENSG00000167711 ENSMUSG00000038224
UniProt P08697 Q61247
RefSeq (mRNA) NM_000934 NM_008878
RefSeq (protein) NP_000925 NP_032904
Location (UCSC) Chr 17:
1.65 – 1.66 Mb
Chr 11:
75.43 – 75.44 Mb
PubMed search [1] [2]

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.[1]

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease[edit]

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease. [2]

Interactions[edit]

Alpha 2-antiplasmin has been shown to interact with:

See also[edit]

References[edit]

  1. ^ "Entrez Gene: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2". 
  2. ^ Sattar, Husain. Fundamentals of Pathology. Pathoma LLC, 2011, p. 36.
  3. ^ a b Shieh BH, Travis J (May 1987). "The reactive site of human alpha 2-antiplasmin". J. Biol. Chem. 262 (13): 6055–9. PMID 2437112. 
  4. ^ Brower MS, Harpel PC (August 1982). "Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase". J. Biol. Chem. 257 (16): 9849–54. PMID 6980881. 
  5. ^ Wiman B, Collen D (September 1979). "On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin". J. Biol. Chem. 254 (18): 9291–7. PMID 158022. 

Further reading[edit]

External links[edit]