Platelet alpha-granule
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(Redirected from Alpha granules)
| Alpha granule | |
|---|---|
| Latin | granulum alpha |
| Code | TH H2.00.04.1.03005 |
In platelets, the term "alpha granules" is used to describe granules containing several growth factors.[1]
Contents |
[edit] Contents
Contents include insulin-like growth factor 1, platelet-derived growth factor, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, and von Willebrand factor.
The alpha granules express the adhesion molecule P-selectin[2] and CD63.[3] These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
[edit] Clinical significance
A deficiency of alpha granules is known as grey platelet syndrome.
[edit] See also
[edit] References
- ^ Harrison P, Cramer E (1993). "Platelet alpha-granules.". Blood Rev 7 (1): 52–62. doi:10.1016/0268-960X(93)90024-X. PMID 8467233.
- ^ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 9781416034308. http://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386. Retrieved 2 November 2010.
- ^ William B. Coleman; Gregory J. Tsongalis (2009). Molecular pathology: the molecular basis of human disease. Academic Press. pp. 258–. ISBN 9780123744197. http://books.google.com/books?id=btloapOq85wC&pg=PA258. Retrieved 2 November 2010.
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