Altanserin

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Altanserin
Altanserin.svg
Systematic (IUPAC) name
3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
Clinical data
Legal status
?
Identifiers
CAS number 76330-71-7 YesY
ATC code None
PubChem CID 3033677
ChemSpider 2298299 YesY
UNII 5015H744JQ YesY
ChEMBL CHEMBL62919 YesY
Chemical data
Formula C22H22FN3O2S 
Mol. mass 411.49 g/mol[1]
 YesY (what is this?)  (verify)

Altanserin is a compound that binds to the 5-HT2A receptor (5-Hydroxytryptamine (serotonin) 2A receptor). Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain, i.e., studies of the 5-HT2A neuroreceptors. Besides human neuroimaging studies altanserin has also been used in the study of rats.[2][3]

An alternative for PET imaging the 5-HT2A receptor is the [11C]MDL 100,907 radioligand. Fluorine-18-altanserin and tritium-MDL 100,907 have shown very comparable binding.[4] Both altanserin and MDL 100,907 are 5-HT2A receptor antagonists.[4] [18F]-setoperone can also be used in PET.

An alternative SPECT radioligand is the [123I]-5-I-R91150 receptor antagonist.[5]

A rapid chemical synthesis of fluorine-18 and H-2 dual-labeled altanserin has been described.[6]

Other ligands for other parts of the serotonin system used in PET studies are, e.g., DASB, ketanserin and WAY-100635.

Human brain mapping studies with altanserin[edit]

A PET scanner. Human experiments with fluorine-18 altanserin are performed in these types of brain scanners.

As of 2007 altanserin is probably not used in clinical routine. However, there have been performed several research-based neuroimaging studies with the compound in humans since the 1990s.[7][8] Some of these studies have considered methodogical issues such as the reproducibility of the method[9][10] or whether to use constant infusion[11] or bolus-infusion[12] delivery of altanserin. Other studies have compared altanserin binding to subject variables such as age, personality trait and neuropsychiatric disorder.

The altanserin PET scan shows high binding in neocortex. The cerebellum is often regarded as a region with no specific 5-HT2A binding and the brain region is used as a reference in some studies, even though an autoradiography study has found nonnegligible levels of 5-HT2A binding in the human cerebellum,[13] and another type of study have observed strong immunoreaction against 5-HT2A receptor protein in rat Purkinje cells.[14]

In the table below is an overview of the results of altanserin binding seen in human PET-studies. A consistent finding across altanserin studies has been that the binding decreases with age. This is in line with in vitro studies of the 5-HT2A receptor,[15] as well as PET studies with other radioligands that binds to the receptor.[16]

The result for recovered bulimia-type anorexia nervosa[17] is in line with a SPECT study of anorexia nervosa patients, that found a decrease in frontal, occipital and parietal cortices.[5] The results of PET studies of the 5-HT2A in depression has been mixed.[18]

Altanserin binding has also been examine in twins, where one study showed higher correlation between monozygotic twin pairs than between dizygotic twin pairs, giving evidence that the binding is "strongly genetically determined".[19]

Altanserin neuroimaging studies
What Result Reference
Sex Higher binding in men [20]
Body mass index Correlation in cortex [21]
Neuroticism (NEO PI-R) Increase in frontolimbic region [22]
Tourette syndrome Increase [23]
Obsessive-compulsive disorder Increase in caudate nuclei [24]
(Recovered) bulimia-type anorexia nervosa Decrease in left subgenual cingulate, left parietal cortex and right occipital cortex [17]
Unipolar depression Decrease in a region in right hemisphere (posterolateral orbitofrontal cortex and the anterior insular cortex) [25]
Major depressive disorder Decrease in hippocampus [26]
Older depressed patients Decrease in hippocampus [27]
Borderline personality disorder Increase in hippocampus [28]
Schizophrenia No significant cortical difference, higher binding in caudate [29]
At-risk mental state Decrease [30] See also [31]
Age Decrease [32]
Age Decrease [33]
Age Decrease in cortical regions (except occipital), increase in cerebellum [34]
Mild cognitive impairment Decrease [35]
Alzheimer's disease Decrease in amygdalo-hippocampal complex and cortical regions, such as anterior cingulate, lateral temporal cortex, prefrontal cortex and sensorimotor cortex [36]

References[edit]

  1. ^ ABX, Altanserin, Radeberg, Germany.
  2. ^ Christian Lemaire, Cantineau, Guillaume, Plenevaux, Christiaens (December 1, 1991). "Fluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats". Journal of Nuclear Medicine 32 (12): 2266–2277. PMID 1744713. 
  3. ^ F. Biver, F. Lotstra, M. Monclus, S. Dethy, P. Damhaut, D. Wikler, A. Luxen and S. Goldman (May 1997). "In vivo binding of [18F]altanserin to rat brain 5HT2 receptors: A film and electronic autoradiographic study". Nuclear Medicine and Biology 24 (4): 357–360. doi:10.1016/S0969-8051(97)00054-1. PMID 9257335. 
  4. ^ a b Heidi Kristiansen, Bettina Elfving, Per Plenge, Lars H. Pinborg, Nic Gillings & Gitte Moos Knudsen; Elfving; Plenge; Pinborg; Gillings; Knudsen (December 2005). "Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907". Synapse 58 (4): 249–257. doi:10.1002/syn.20205. PMID 16206185. 
  5. ^ a b Kurt Audenaert, Koen Van Laere, Filip Dumont, Miriam Vervaet, Ingeborg Goethals, Guido Slegers, John Mertens, Cees van Heeringen, Rudi A. Dierckx; Van Laere; Dumont; Vervaet; Goethals; Slegers; Mertens; Van Heeringen; Dierckx (2003). "Decreased 5-HT2A Receptor Binding in Patients with Anorexia Nervosa". Journal of Nuclear Medicine 44 (2): 163–169. PMID 12571204. 
  6. ^ Ping-Zhong Tan, Baldwin, Fu, Charney, Innis (May 1999). "Rapid synthesis of F-18 and H-2 dual-labeled altanserin, a metabolically resistant PET ligand for 5-HT2a receptors". Journal of Labelled Compounds and Radiopharmaceuticals 42 (5): 457–467. doi:10.1002/(SICI)1099-1344(199905)42:5<457::AID-JLCR206>3.0.CO;2-0. 
  7. ^ Frangoise Biver, Serge Goldman, André Luxen, Michel Monclus, Manuel Forestini, Julien Mendlewicz and Françoise Lotstra (September 1994). "Multicompartmental study of fluorine-18 altanserin binding to brain 5HT2 receptors in humans using positron emission tomography". European Journal of Nuclear Medicine and Molecular Imaging 21 (9): 937–946. doi:10.1007/BF00238117. 
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  9. ^ Gwenn S. Smith, Julie C. Price, Brian J. Lopresti, Yiyun Huang, Norman Simpson, Daniel Holt, N. Scott Mason, Carolyn Cidis Meltzer, Robert A. Sweet, Thomas Nichols, Donald Sashin, Chester A. Mathis; Price; Lopresti; Huang; Simpson; Holt; Mason; Cidis Meltzer; Sweet; Nichols; Sashin; Mathis (1998). "Test-retest variability of serotonin 5-HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain". Synapse 30 (4): 380–392. doi:10.1002/(SICI)1098-2396(199812)30:4<380::AID-SYN5>3.0.CO;2-U. 
  10. ^ Steven Haugbøl, Lars H. Pinborg, Haroon M. Arfan, Vibe Frøkjær, Jacob Madsen, Tim B. Dyrby, Claus Svarer and Gitte M. Knudsen (June 2007). "Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach". European Journal of Nuclear Medicine and Molecular Imaging 34 (6): 910–915. doi:10.1007/s00259-006-0296-y. PMID 17195073. 
  11. ^ Christopher H. van Dyck, Ping-Zhong Tan, Ronald M. Baldwin, Louis A. Amici, Pradeep K. Garg, Chin K. Ng, Robert Soufer, Dennis S. Charney and Robert B. Innis (February 1, 2000). "PET Quantification of 5-HT2A Receptors in the Human Brain: A Constant Infusion Paradigm with [18F]Altanserin". The Journal of Nuclear Medicine 41 (2): 234–241. PMID 10688105. 
  12. ^ Lars H Pinborg, Karen H Adams, Claus Svarer, Søren Holm*, Steen G Hasselbalch, Steven Haugbøl, Jacob Madsen and Gitte M Knudsen (2003). "Quantification of 5-HT2A Receptors in the Human Brain Using [18F]Altanserin-PET and the Bolus/Infusion Approach". Journal of Cerebral Blood Flow & Metabolism 23 (8): 985–996. doi:10.1097/01.WCB.0000074092.59115.23. PMID 12902843. 
  13. ^ Sharon L. Eastwood, Philip W. J. Burnet, Rebecca Gittins, Kate Baker, Paul J. Harrison; Burnet; Gittins; Baker; Harrison (November 2001). "Expression of serotonin 5-HT2A receptors in the human cerebellum and alterations in schizophrenia". Synapse 42 (2): 104–114. doi:10.1002/syn.1106. PMID 11574947. 
  14. ^ Toru Maeshima, Shutoh, Hamada, Senzaki, Hamaguchi-Hamada, Ito, Okado (August 1998). "Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells". Neuroscience Letters 252 (1): 72–74. doi:10.1016/S0304-3940(98)00546-1. PMID 9756362. 
  15. ^ Jan O. Marcusson, Morgan, Winblad, Finch (October 1984). "Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age". Brain Research 311 (1): 51–56. doi:10.1016/0006-8993(84)91397-0. PMID 6488044. 
  16. ^ D. F. Wong et al. (December 1984). "Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain". Science 226 (4681): 1393–1396. doi:10.1126/science.6334363. PMID 6334363. 
  17. ^ a b Ursula F. Bailer, Julie C. Price, Carolyn C. Meltzer, Chester A. Mathis, Guido K. Frank, Lisa Weissfeld, Claire W. McConaha, Shannan E. Henry, Sarah Brooks-Achenbach, Nicole C. Barbarich, and Walter H. Kaye (2004). "Altered 5-HT2A receptor binding after recovery from bulimia-type anorexia nervosa: Relationships to harm avoidance and drive for thinness" (PDF). Neuropsychopharmacology 29 (6): 1143–1155. doi:10.1038/sj.npp.1300430. PMID 15054474. 
  18. ^ Masahiro Fujita, Dennis S. Charneya, c and Robert B. Innis (October 2000). "Imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations". Biological Psychiatry 48 (8): 801–812. doi:10.1016/S0006-3223(00)00960-4. PMID 11063976. 
  19. ^ Lars H. Pinborg, Arfan, Haugbol, Kyvik, Hjelmborg, Svarer, Frokjaer, Paulson, Holm, Knudsen (April 2008). "The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined". NeuroImage 40 (3): 1175–1170. doi:10.1016/j.neuroimage.2007.09.019. PMID 18291676. 
  20. ^ Françoise Biver, Françoise Lotstra, Michel Monclus, David Wikler, Philippe Damhaut, Julien Mendlewicz and Serge Goldman (February 1996). "Sex difference in 5HT2 receptor in the living human brain". Neuroscience Letters 204 (1–2): 25–28. doi:10.1016/0304-3940(96)12307-7. PMID 8929969. 
  21. ^ D. Erritzoe; V.G. Frokjaer; S. Haugbol; L. Marner; C. Svarer; K. Holst; W.F.C. Baaré; P.M. Rasmussen; J. Madsen et al. (May 2009). "Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use". NeuroImage 46 (1): 23–30. doi:10.1016/j.neuroimage.2009.01.050. PMID 19457377. 
  22. ^ Vibe G. Frøkjær, Mortensen, Nielsen, Haugbol, Pinborg, Adams, Svarer, Hasselbalch, Holm, Paulson, Knudsen (2008). "Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective Disorder". Biological Psychiatry 63 (6): 569–76. doi:10.1016/j.biopsych.2007.07.009. PMID 17884017. 
  23. ^ Steven Haugbøl, Pinborg, Lars H., Regeur, Lisbeth, Hansen, Elsebet S., Bolwig, Tom G., Nielsen, Finn Å., Svarer, Claus, Skovgaard, Lene T., Knudsen, Gitte M. (2008). "Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome". The International Journal of Neuropsychopharmacology 10 (2): 245–52. doi:10.1017/S1461145706006559. PMID 16945163. 
  24. ^ K. H. Adams, Hansen, Pinborg, Hasselbalch, Svarer, Holm, Bolwig, Knudsen (September 2005). "Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei". International Journal of Neuropsychopharmacology 8 (3): 391–401. doi:10.1017/S1461145705005055. PMID 15801987. 
  25. ^ F. Biver, D. Wikler, F. Lotstra, P. Damhaut, S. Goldman, J. Mendlewicz; Wikler; Lotstra; Damhaut; Goldman; Mendlewicz (November 1997). "Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex". British Journal of Psychiatry 171 (5): 444–448. doi:10.1192/bjp.171.5.444. PMID 9463603. 
  26. ^ Mark A. Mintun, Yvette I. Sheline, Stephen M. Moerlein, Andrei G. Vlassenko, Abraham Z. Snyder (February 2004). "Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography". Biological Psychiatry 55 (3): 217–224. doi:10.1016/j.biopsych.2003.08.015. PMID 14744461. 
  27. ^ Yvette I. Sheline, Mintun, Barch, Wilkins, Snyder, Moerlein (December 2004). "Decreased hippocampal 5-HT2A receptor binding in older depressed patients using [18F]altanserin positron emission tomography". Neuropsychopharmacology 29 (12): 2235–2241. doi:10.1038/sj.npp.1300555. PMID 15367923. 
  28. ^ P. Soloff, J. Price, C. Meltzer, A. Fabio, G. Frank, W. Kaye; Price; Meltzer; Fabio; Frank; Kaye (2007). "5HT2A Receptor Binding is Increased in Borderline Personality Disorder". Biological Psychiatry 62 (6): 580–587. doi:10.1016/j.biopsych.2006.10.022. PMID 17448449. 
  29. ^ David Erritzoe, Rasmussen, Kristiansen, Frokjaer, Haugbol, Pinborg, Baaré, Svarer, Madsen, Lublin, Knudsen, Glenthoj (February 2008). "Cortical and Subcortical 5-HT2A Receptor Binding in Neuroleptic-Naive First-Episode Schizophrenic Patients". Neuropsychopharmacology 62 (10): 2435–41. doi:10.1038/sj.npp.1301656. PMID 18288096.  Electronic publication ahead of print
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  32. ^ A. Rosier, P. Dupont, J. Peuskens, G. Bormans, R. Vandenberghe, M. Maes, T. de Groot, C. Schiepers, A. Verbruggen, L. Mortelmans; Dupont; Peuskens; Bormans; Vandenberghe; Maes; De Groot; Schiepers; Verbruggen; Mortelmans (November 1996). "Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging". Psychiatry Research 68 (1): 11–22. doi:10.1016/S0925-4927(96)02806-5. PMID 9027929. 
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  34. ^ K. H. Adams, Pinborg, Svarer, Hasselbalch, Holm, Haugbøl, Madsen, Frøkjaer, Martiny, Paulson, Knudsen (March 2004). "A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables". Neuroimage 21 (3): 1105–1113. doi:10.1016/j.neuroimage.2003.10.046. PMID 15006678. 
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