Amanullin

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Amanullin
Amanullin structure.png
Amanullin with tube model.png
Names
Other names
3-Isoleucine-alpha-amanitin
Identifiers
21803-57-6 YesY
ChemSpider 102814 YesY
Jmol-3D images Image
Image
PubChem 114856
Properties
C39H54N10O12S
Molar mass 886.86 g/mol
Appearance Colorless, crystalline solid
Soluble
Solubility in ethanol, methanol Soluble
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.

Toxicology[edit]

Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

See also[edit]

References[edit]

  1. ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749. 

External links[edit]