|Systematic (IUPAC) name|
|Pregnancy cat.||B (US)|
|Legal status||Prescription Only (S4) (AU) POM (UK) Schedule IV (US)|
|Half-life||4-6 hours (metabolites)|
|Mol. mass||205.30 g/mol|
|(what is this?)|
Amfepramone (INN), or diethylpropion (BAN and AAN) also known by the chemical name diethylcathinone and the trade names Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil, Tenuate, is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.
Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone. Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively. As a result, ethcathinone and amfepramone can essentially be considered norepinephrine releasing agents (NRAs).
Amfepramone is classified as a Schedule IV controlled substance in the United States. In the UK Amfepramone is a class C drug  and as a medicine, it is a Schedule 3 Controlled Drug which requires safe custody.
- Propiophenone is brominated to produce α-bromopropiophenone.
- This is reacted with diethylamine to yield the product, diethylpropion.
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