Amphenicol

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Amphenicols are a class of antibiotics with a phenylpropanoid structure. They function by blocking the enzyme peptidyl transferase on the 50S ribosome subunit of bacteria.[1]

Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product, but all amphenicols are now made by chemical synthesis.

References[edit]

  1. ^ APVMA: Florfenicol